The anatomy of a nucleus: As revealed by chromosome painting

About the Authors: Brian D. Slaughter Affiliation: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America ORCID logo http://orcid.org/0000-0001-8305-8395 R. Scott Hawley * E-mail: rsh@stowers.org Affiliations Stowers Institute for Medical Research, Kansas City, Misso...

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Bibliographic Details
Published in:PLoS genetics 2018-07, Vol.14 (7), p.e1007445-e1007445
Main Authors: Slaughter, Brian D, Hawley, R Scott
Format: Article
Language:English
Subjects:
Adenosine Triphosphatases
Anatomy
Animals
Biology and Life Sciences
Cell cycle
Cell nucleus
Chromosome Painting
Chromosomes
Computer applications
Cytological research
Deoxyribonucleic acid
Design
DNA
DNA-Binding Proteins
Drosophila
Gene expression
Genetic aspects
Genetic research
Genomes
Insects
Interphase
Karyotyping
Medical research
Multiprotein Complexes
Physiological aspects
Research and Analysis Methods
Slaughter
Structural painting
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Summary:About the Authors: Brian D. Slaughter Affiliation: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America ORCID logo http://orcid.org/0000-0001-8305-8395 R. Scott Hawley * E-mail: rsh@stowers.org Affiliations Stowers Institute for Medical Research, Kansas City, Missouri, United States of America, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America ORCID logo http://orcid.org/0000-0002-6478-0494 Citation: Slaughter BD, Hawley RS (2018) The anatomy of a nucleus: By using these custom oligo probe groups in combination with automated computational methods, one can search both for features of large-scale chromosome organization and for unique features of single cells that may be correlated back to gene expression or aberrant cellular function. [...]they used this Oligopaint library to provide exquisite detail on how chromosome territories are conserved in different Drosophila cell types. [...]the authors demonstrate that the general layout of chromosome territories appears to be conserved in different Drosophila cell types.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1007445