Frequent detection of Saffold cardiovirus in adenoids

Saffold virus (SAFV) is classified into the Cardiovirus genus of the Picornaviridae family. Up to now, eleven genotypes have been identified however, their clinical significance remains unclear. Here, we investigated the presence of SAFV in asymptomatic patients admitted for adenoidectomy. A total o...

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Bibliographic Details
Published in:PloS one 2019-07, Vol.14 (7), p.e0218873-e0218873
Main Authors: Lindner, Kira, Ludwig, Michael, Bootz, Friedrich, Reber, Ulrike, Safavieh, Zahrasadat, Eis-Hübinger, Anna Maria, Herberhold, Stephan
Format: Article
Language:English
Subjects:
Adenoid
Adenoidectomy
Adenoids
Adenoids - pathology
Adenoids - virology
Biology and life sciences
Cardiovirus - isolation & purification
Cardiovirus - pathogenicity
Child
Child, Preschool
Children
Chronic infection
Female
Genetic research
Genotype
Genotypes
Humans
Hypertrophy
Hypertrophy - pathology
Hypertrophy - virology
Infection
Infections
Male
Medical research
Medicine and Health Sciences
Meningitis
Multiple sclerosis
Nasopharynx - virology
Nucleic acids
Otolaryngology
People and Places
Picornaviridae - isolation & purification
Picornaviridae - pathogenicity
Polymerase chain reaction
Research and Analysis Methods
Respiratory tract
Signs and symptoms
Surgery
Tonsillitis
Transcription (Genetics)
Virology
Viruses
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Summary:Saffold virus (SAFV) is classified into the Cardiovirus genus of the Picornaviridae family. Up to now, eleven genotypes have been identified however, their clinical significance remains unclear. Here, we investigated the presence of SAFV in asymptomatic patients admitted for adenoidectomy. A total of 70 adenoid tissue samples were collected from children with clinical symptoms caused by hypertrophy of adenoids but without symptoms of airway infection. Samples were investigated for SAFV by RT-nested PCR and sequence analysis. Eleven of 70 (15.7%) samples were positive for SAFV. Nasopharyngeal swabs were available from 45 children just before surgery. SAFV was rarely found and only in children with SAFV-positive adenoids 2/8. Our findings indicate that the presence of SAFV seems to be more frequent in adenoid tissue than expected. This could support the notion of a longer than previously anticipated persistence of SAFV nucleic acids in the respiratory tract and possibly a chronic infection. Further investigations are necessary to establish the role of SAFV infection in humans.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0218873