Diagnostic tests, drug prescriptions, and follow-up patterns after incident heart failure: A cohort study of 93,000 UK patients

• Published in: PLoS medicine 2019-05, Vol.16 (5), p.e1002805-e1002805
• Main Authors: Conrad, Nathalie, Judge, Andrew, Canoy, Dexter, Tran, Jenny, O'Donnell, Johanna, Nazarzadeh, Milad, Salimi-Khorshidi, Gholamreza, Hobbs, F D Richard, Cleland, John G, McMurray, John J V, Rahimi, Kazem
• Format: Article
• Language: English
• Subjects: Adrenergic beta-antagonists; Age; Aged; Aged, 80 and over; Angiotensin; Angiotensins; Archives & records; Biomedical research; Cardiac patients; Cardiovascular Agents - therapeutic use; Care and treatment; Chronic diseases; Chronic illnesses; Clinical medicine; Cohort analysis; Congestive heart failure; Diagnosis; Diagnostic Techniques, Cardiovascular - trends; Diagnostic tests; Disease management; Drug dosages; Drug Prescriptions; Drugs; Elderly; Employee performance; Enzyme inhibitors; Enzymes; Epidemiology; Evidence-based medicine; Female; Health Care Surveys; Healthcare Disparities - trends; Heart failure; Heart Failure - diagnosis; Heart Failure - drug therapy; Heart Failure - epidemiology; Hospital admission and discharge; Hospitals; Humans; Incidence; Indicators; Long term care; Male; Medical prognosis; Medical records; Medical research; Medical tests; Medicine; Medicine and Health Sciences; Middle Aged; Older people; Patients; Physicians; Population studies; Practice Patterns, Physicians' - trends; Predictive Value of Tests; Primary care; Professional Practice Gaps - trends; Quality; Quality control; Regression analysis; Retrospective Studies; Risk Factors; Sex Factors; Social Class; Socioeconomic factors; Socioeconomics; Studies; Supervision; Time Factors; Titration; Treatment Outcome; Trends; United Kingdom - epidemiology; Ventricle
• ISSN: 1549-1676; 1549-1277; 1549-1676
• DOI: 10.1371/journal.pmed.1002805

Effective management of heart failure is complex, and ensuring evidence-based practice presents a major challenge to health services worldwide. Over the past decade, the United Kingdom introduced a series of national initiatives to improve evidence-based heart failure management, including a landmark pay-for-performance scheme in primary care and a national audit in secondary care started in 2004 and 2007, respectively. Quality improvement efforts have been evaluated within individual clinical settings, but patterns of care across its continuum, although a critical component of chronic disease management, have not been studied. We have designed this study to investigate patients' trajectories of care around the time of diagnosis and their variation over time by age, sex, and socioeconomic status. For this retrospective population-based study, we used linked primary and secondary health records from a representative sample of the UK population provided by the Clinical Practice Research Datalink (CPRD). We identified 93,074 individuals newly diagnosed with heart failure between 2002 and 2014, with a mean age of 76.7 years and of which 49% were women. We examined five indicators of care: (i) diagnosis care setting (inpatient or outpatient), (ii) posthospitalisation follow-up in primary care, (iii) diagnostic investigations, (iv) prescription of essential drugs, and (v) drug treatment dose. We used Poisson and linear regression models to calculate category-specific risk ratios (RRs) or adjusted differences and 95% confidence intervals (CIs), adjusting for year of diagnosis, age, sex, region, and socioeconomic status. From 2002 to 2014, indicators of care presented diverging trends. Outpatient diagnoses and follow-up after hospital discharge in primary care declined substantially (ranging from 56% in 2002 to 36% in 2014, RR 0.64 [0.62, 0.67] and 20% to 14%, RR 0.73 [0.65, 0.82], respectively). Primary care referral for diagnostic investigations and appropriate initiation of beta blockers and angiotensin-converting-enzyme inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs) both increased significantly (37% versus 82%, RR 2.24 [2.15, 2.34] and 18% versus 63%, RR 3.48 [2.72, 4.43], respectively). Yet, the average daily dose prescribed remained below guideline recommendations (42% for ACE-Is or ARBs, 29% for beta blockers in 2014) and was largely unchanged beyond the first 30 days after diagnosis. Despite increasing rates of treatment initiation, the overal