Human-pathogenic Anaplasma spp., and Rickettsia spp. in animals in Xi'an, China

In China, thirteen species of tick-borne rickettsiales bacteria pathogenic to human have been reported in ticks and host animals, and human patients caused by them also has been identified. However, investigation for rickettsiales bacteria circulating in Xi'an wasn't performed although dis...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2018-11, Vol.12 (11), p.e0006916-e0006916
Main Authors: Guo, Wen-Ping, Huang, Baicheng, Zhao, Qin, Xu, Gang, Liu, Baoyuan, Wang, Yi-Han, Zhou, En-Min
Format: Article
Language:English
Subjects:
Anaplasma
Animals
Arachnids
Bacteria
Beef cattle
Biology and Life Sciences
Computer and Information Sciences
Deoxyribonucleic acid
Disease
Disease prevention
DNA
Domestic animals
Epidemiology
Fever
Genes
Genetic aspects
Genetic testing
Goats
Health aspects
Health risks
Human diseases
Identification
Infections
Medicine and Health Sciences
Methods
Novels
Pathogenicity
Pathogens
Pharmacology
Phylogenetic trees
Phylogeny
Public health
Rickettsia
Risk factors
Rrs gene
Sheep
Species
Tick-borne diseases
Ticks
Tropical diseases
Veterinary colleges
Veterinary medicine
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Description
Summary:In China, thirteen species of tick-borne rickettsiales bacteria pathogenic to human have been reported in ticks and host animals, and human patients caused by them also has been identified. However, investigation for rickettsiales bacteria circulating in Xi'an wasn't performed although diseases resembling human diseases caused by these organisms have been found. In this study, domestic animals and ticks in Xi'an, China, were tested for the presence of rickettsiales bacteria pathogenic to humans. Besides A. ovis, a high prevalence of A. capra was observed suggesting a high public health risk exists. In addition, two novel Anaplasma species closely related to A. phagocytophilum were identified and formed distinct lineages in the phylogenetic trees, with more than 98.3% identities for rrs gene, while divergences up to 20.2% and 37.0% for groEL and gltA genes, respectively. Both of these two novel Anaplasma species were found to circulate in goats and further assessment of their pathogenicity is needed. Ca. R. jingxinensis, with potential pathogenicity, was also detected in H. longicomis ticks with high prevalence. However, other causative agents were not identified although they were distributed in other areas of China.
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0006916