Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia

This study investigated the effects of hydroxyurea (HU) on hematological, biochemical and inflammatory parameters in children with sickle cell anemia (SCA) in association with βS haplotype and α-thalassemia. We included 22 children with SCA who were followed for an average of 14.5 months. Laboratory...

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Published in:PloS one 2019-07, Vol.14 (7), p.e0218040-e0218040
Main Authors: Yahouédéhou, Sètondji Cocou Modeste Alexandre, da Guarda, Caroline Conceição, Figueiredo, Camylla Vilas Boas, Santiago, Rayra Pereira, Carvalho, Suellen Pinheiro, Fiuza, Luciana Magalhães, Ndidi, Uche Samuel, Oliveira, Rodrigo Mota, Carvalho, Magda Oliveira Seixas, Nascimento, Valma Maria Lopes, Rocha, Larissa Carneiro, Lyra, Isa Menezes, Adorno, Elisângela Vitória, Goncalves, Marilda Souza
Format: Article
Language:English
Subjects:
Albumin
alpha-Thalassemia - blood
alpha-Thalassemia - drug therapy
Anemia
Anemia, Sickle Cell - blood
Anemia, Sickle Cell - drug therapy
Bilirubin
Bilirubin - blood
Biology and Life Sciences
Biomarkers
Biomarkers - blood
Blood
Blood Glucose - metabolism
Child
Child, Preschool
Children
Clonal deletion
Eosinophils
Erythrocyte Indices
Female
Fetal Hemoglobin - metabolism
Haplotypes
Hematocrit
Hematology
Hemoglobin
High density lipoprotein
Humans
Hydroxyurea
Hydroxyurea - administration & dosage
Infant
Inflammation
Inflammation - blood
Inflammation - drug therapy
Laboratories
Leukocyte Count
Leukocytes (eosinophilic)
Leukocytes (neutrophilic)
Lipids
Lymphocytes
Male
Medicine and Health Sciences
Metabolism
Parameters
Polymerase chain reaction
Pregnancy
Restriction fragment length polymorphism
Reticulocyte Count
Reticulocytes
Sickle cell anemia
Sickle cell disease
Thalassemia
Therapy
Triglycerides
Uric acid
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cited_by cdi_FETCH-LOGICAL-c526t-f901b687474a818433f8c8472f94ed02b1e3a2e5119185a76a5feefe8a65d81d3
cites cdi_FETCH-LOGICAL-c526t-f901b687474a818433f8c8472f94ed02b1e3a2e5119185a76a5feefe8a65d81d3
container_end_page e0218040
container_issue 7
container_start_page e0218040
container_title PloS one
container_volume 14
creator Yahouédéhou, Sètondji Cocou Modeste Alexandre
da Guarda, Caroline Conceição
Figueiredo, Camylla Vilas Boas
Santiago, Rayra Pereira
Carvalho, Suellen Pinheiro
Fiuza, Luciana Magalhães
Ndidi, Uche Samuel
Oliveira, Rodrigo Mota
Carvalho, Magda Oliveira Seixas
Nascimento, Valma Maria Lopes
Rocha, Larissa Carneiro
Lyra, Isa Menezes
Adorno, Elisângela Vitória
Goncalves, Marilda Souza
description This study investigated the effects of hydroxyurea (HU) on hematological, biochemical and inflammatory parameters in children with sickle cell anemia (SCA) in association with βS haplotype and α-thalassemia. We included 22 children with SCA who were followed for an average of 14.5 months. Laboratory parameters were assessed by electronic methods, and molecular analysis was investigated by PCR-RFLP and allele-specific PCR. Results showed significant increases in hemoglobin, HbF, hematocrit, MCV, MCH, glucose, HDL-C and albumin levels, as well as significant decreases in MCHC and AST levels, WBC, neutrophils, eosinophils, lymphocytes and reticulocytes, in children during HU therapy. HbF levels were positively correlated with hemoglobin, hematocrit, MCV and total protein, yet negatively correlated with MCHC, RDW, AAT and AST during HU therapy (p
doi_str_mv 10.1371/journal.pone.0218040
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We included 22 children with SCA who were followed for an average of 14.5 months. Laboratory parameters were assessed by electronic methods, and molecular analysis was investigated by PCR-RFLP and allele-specific PCR. Results showed significant increases in hemoglobin, HbF, hematocrit, MCV, MCH, glucose, HDL-C and albumin levels, as well as significant decreases in MCHC and AST levels, WBC, neutrophils, eosinophils, lymphocytes and reticulocytes, in children during HU therapy. HbF levels were positively correlated with hemoglobin, hematocrit, MCV and total protein, yet negatively correlated with MCHC, RDW, AAT and AST during HU therapy (p&lt;0.05). Children who carried the Central African Republic haplotype, in response to HU therapy, presented significant increases in hemoglobin, hematocrit, triglycerides and uric acid levels, as well as significant decreases in MCHC, AST and direct bilirubin levels, WBC, neutrophils, eosinophils, lymphocytes and reticulocytes. Those with the Benin haplotype presented increases in HbF and albumin levels, and a reduction in platelet counts (p&lt;0.05). Children with α-thalassemia presented decreased ALT during HU use, while those without this deletion presented increases in hemoglobin, hematocrit, MCV, MCH, HDL-C and albumin, as well as decreases in MCHC, neutrophils, lymphocytes, reticulocytes and AST (p&lt;0.05). 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da Guarda, Caroline Conceição ; Figueiredo, Camylla Vilas Boas ; Santiago, Rayra Pereira ; Carvalho, Suellen Pinheiro ; Fiuza, Luciana Magalhães ; Ndidi, Uche Samuel ; Oliveira, Rodrigo Mota ; Carvalho, Magda Oliveira Seixas ; Nascimento, Valma Maria Lopes ; Rocha, Larissa Carneiro ; Lyra, Isa Menezes ; Adorno, Elisângela Vitória ; Goncalves, Marilda Souza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-f901b687474a818433f8c8472f94ed02b1e3a2e5119185a76a5feefe8a65d81d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Albumin</topic><topic>alpha-Thalassemia - blood</topic><topic>alpha-Thalassemia - drug therapy</topic><topic>Anemia</topic><topic>Anemia, Sickle Cell - blood</topic><topic>Anemia, Sickle Cell - drug therapy</topic><topic>Bilirubin</topic><topic>Bilirubin - blood</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood</topic><topic>Blood Glucose - metabolism</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Clonal deletion</topic><topic>Eosinophils</topic><topic>Erythrocyte Indices</topic><topic>Female</topic><topic>Fetal Hemoglobin - metabolism</topic><topic>Haplotypes</topic><topic>Hematocrit</topic><topic>Hematology</topic><topic>Hemoglobin</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>Hydroxyurea</topic><topic>Hydroxyurea - administration &amp; 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Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest - Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yahouédéhou, Sètondji Cocou Modeste Alexandre</au><au>da Guarda, Caroline Conceição</au><au>Figueiredo, Camylla Vilas Boas</au><au>Santiago, Rayra Pereira</au><au>Carvalho, Suellen Pinheiro</au><au>Fiuza, Luciana Magalhães</au><au>Ndidi, Uche Samuel</au><au>Oliveira, Rodrigo Mota</au><au>Carvalho, Magda Oliveira Seixas</au><au>Nascimento, Valma Maria Lopes</au><au>Rocha, Larissa Carneiro</au><au>Lyra, Isa Menezes</au><au>Adorno, Elisângela Vitória</au><au>Goncalves, Marilda Souza</au><au>Arez, Ana Paula</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-07-15</date><risdate>2019</risdate><volume>14</volume><issue>7</issue><spage>e0218040</spage><epage>e0218040</epage><pages>e0218040-e0218040</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This study investigated the effects of hydroxyurea (HU) on hematological, biochemical and inflammatory parameters in children with sickle cell anemia (SCA) in association with βS haplotype and α-thalassemia. We included 22 children with SCA who were followed for an average of 14.5 months. Laboratory parameters were assessed by electronic methods, and molecular analysis was investigated by PCR-RFLP and allele-specific PCR. Results showed significant increases in hemoglobin, HbF, hematocrit, MCV, MCH, glucose, HDL-C and albumin levels, as well as significant decreases in MCHC and AST levels, WBC, neutrophils, eosinophils, lymphocytes and reticulocytes, in children during HU therapy. HbF levels were positively correlated with hemoglobin, hematocrit, MCV and total protein, yet negatively correlated with MCHC, RDW, AAT and AST during HU therapy (p&lt;0.05). Children who carried the Central African Republic haplotype, in response to HU therapy, presented significant increases in hemoglobin, hematocrit, triglycerides and uric acid levels, as well as significant decreases in MCHC, AST and direct bilirubin levels, WBC, neutrophils, eosinophils, lymphocytes and reticulocytes. Those with the Benin haplotype presented increases in HbF and albumin levels, and a reduction in platelet counts (p&lt;0.05). Children with α-thalassemia presented decreased ALT during HU use, while those without this deletion presented increases in hemoglobin, hematocrit, MCV, MCH, HDL-C and albumin, as well as decreases in MCHC, neutrophils, lymphocytes, reticulocytes and AST (p&lt;0.05). Hence, regardless of its use in association with βS haplotypes or α-thalassemia, HU seems to be linked to alterations in hemolytic, inflammatory, hepatic, lipid and glycemic profiles.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31306416</pmid><doi>10.1371/journal.pone.0218040</doi><orcidid>https://orcid.org/0000-0003-3000-1437</orcidid><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1932-6203
ispartof PloS one, 2019-07, Vol.14 (7), p.e0218040-e0218040
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_2258360006
source PubMed Central (Open Access); ProQuest - Publicly Available Content Database
subjects Albumin
alpha-Thalassemia - blood
alpha-Thalassemia - drug therapy
Anemia
Anemia, Sickle Cell - blood
Anemia, Sickle Cell - drug therapy
Bilirubin
Bilirubin - blood
Biology and Life Sciences
Biomarkers
Biomarkers - blood
Blood
Blood Glucose - metabolism
Child
Child, Preschool
Children
Clonal deletion
Eosinophils
Erythrocyte Indices
Female
Fetal Hemoglobin - metabolism
Haplotypes
Hematocrit
Hematology
Hemoglobin
High density lipoprotein
Humans
Hydroxyurea
Hydroxyurea - administration & dosage
Infant
Inflammation
Inflammation - blood
Inflammation - drug therapy
Laboratories
Leukocyte Count
Leukocytes (eosinophilic)
Leukocytes (neutrophilic)
Lipids
Lymphocytes
Male
Medicine and Health Sciences
Metabolism
Parameters
Polymerase chain reaction
Pregnancy
Restriction fragment length polymorphism
Reticulocyte Count
Reticulocytes
Sickle cell anemia
Sickle cell disease
Thalassemia
Therapy
Triglycerides
Uric acid
title Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia
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