Factors associated with moderate neonatal hyperthyrotropinemia

• Published in: PloS one 2019-07, Vol.14 (7), p.e0220040-e0220040
• Main Authors: Cortés-Castell, Ernesto, Juste, Mercedes, Palazón-Bru, Antonio, Goicoechea, Mercedes, Gil-Guillén, Vicente Francisco, Rizo-Baeza, María Mercedes
• Format: Article
• Language: English
• Subjects: Adult; Age; Biology and Life Sciences; Birth; Birth weight; Blood; Case-Control Studies; Clinical medicine; Congenital diseases; Control methods; Cystic fibrosis; Dietary supplements; Disease control; Ethnicity; Female; Genetic aspects; Genetic disorders; Gestational age; Hormones; Humans; Hyperthyroxinemia - diagnosis; Hyperthyroxinemia - etiology; Hyperthyroxinemia - metabolism; Hypothyroidism; Infant, Newborn; Infant, Newborn, Diseases; Iodine; Laboratories; Male; Males; Medical research; Medical screening; Medicine and Health Sciences; Minority & ethnic groups; Neonatal Screening; Neonates; Newborn babies; Newborn infants; Nutrition; Odds Ratio; Organic chemistry; Pediatrics; People and Places; Physical Sciences; Physiological aspects; Pituitary hormones; Population; Pregnancy; Premature birth; Quality control; Regression analysis; Regression models; Risk analysis; Risk Assessment; Risk Factors; Risk groups; Severity of Illness Index; Sex; Thyroid; Thyroid gland; Thyroid hormones; Thyroid-stimulating hormone; Thyrotropin; Thyrotropin - metabolism; Variables
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0220040

Maternal iodine deficiency is related to high neonatal thyroid-stimulating hormone (TSH) values, with the threshold of 5 mIU/L recommended as an indicator of iodine nutrition status. The objective of this study was to analyse possible risk factors for increased TSH that could distort its validity as a marker of iodine status. The clinical relevance of this research question is that if the factors associated with iodine deficiency are known, iodine supplementation can be introduced in risk groups, both during pregnancy and in newborns. A case-control study was carried out in a sample of 46,622 newborns in 2002-2015 in Spain. Of these, 45,326 had a neonatal TSH value ≥5 mIU/L. The main variable was having TSH ≥5 mIU/L and the secondary variables were: sex, gestational age, day of sample extraction and maternal origin. Associated factors were analysed through a logistic regression model, calculating the odds ratio (OR). The factors associated with this outcome were: male sex (OR = 1.34, 95% CI: 1.20-1.50, p