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Vector competence of biting midges and mosquitoes for Shuni virus
Shuni virus (SHUV) is an orthobunyavirus that belongs to the Simbu serogroup. SHUV was isolated from diverse species of domesticated animals and wildlife, and is associated with neurological disease, abortions, and congenital malformations. Recently, SHUV caused outbreaks among ruminants in Israel,...
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| Published in: | PLoS neglected tropical diseases 2018-12, Vol.12 (12), p.e0006993-e0006993 |
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| creator | Möhlmann, Tim W R Oymans, Judith Wichgers Schreur, Paul J Koenraadt, Constantianus J M Kortekaas, Jeroen Vogels, Chantal B F |
| description | Shuni virus (SHUV) is an orthobunyavirus that belongs to the Simbu serogroup. SHUV was isolated from diverse species of domesticated animals and wildlife, and is associated with neurological disease, abortions, and congenital malformations. Recently, SHUV caused outbreaks among ruminants in Israel, representing the first incursions outside the African continent. The isolation of SHUV from a febrile child in Nigeria and seroprevalence among veterinarians in South Africa suggests that the virus may have zoonotic potential as well. The high pathogenicity, extremely broad tropism, potential transmission via both biting midges and mosquitoes, and zoonotic features warrants prioritization of SHUV for further research. Additional knowledge is essential to accurately determine the risk for animal and human health, and to assess the risk of future epizootics and epidemics. To gain first insights into the potential involvement of arthropod vectors in SHUV transmission, we have investigated the ability of SHUV to infect and disseminate in laboratory-reared biting midges and mosquitoes.
Culicoides nubeculosus, C. sonorensis, Culex pipiens pipiens, and Aedes aegypti were orally exposed to SHUV by providing an infectious blood meal. Biting midges showed high infection rates of approximately 40-60%, whereas infection rates of mosquitoes were lower than 2%. SHUV successfully disseminated in both species of biting midges, but no evidence of transmission in orally exposed mosquitoes was found.
The results of this study show that different species of Culicoides biting midges are susceptible to infection and dissemination of SHUV, whereas the two mosquito species tested were found not to be susceptible. |
| doi_str_mv | 10.1371/journal.pntd.0006993 |
| format | article |
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Culicoides nubeculosus, C. sonorensis, Culex pipiens pipiens, and Aedes aegypti were orally exposed to SHUV by providing an infectious blood meal. Biting midges showed high infection rates of approximately 40-60%, whereas infection rates of mosquitoes were lower than 2%. SHUV successfully disseminated in both species of biting midges, but no evidence of transmission in orally exposed mosquitoes was found.
The results of this study show that different species of Culicoides biting midges are susceptible to infection and dissemination of SHUV, whereas the two mosquito species tested were found not to be susceptible.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0006993</identifier><identifier>PMID: 30532189</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aedes - virology ; Amino acids ; Animals ; Antibiotics ; Aquatic insects ; Biology and Life Sciences ; Biting ; Bunyaviridae Infections - transmission ; Bunyaviridae Infections - virology ; Bunyaviruses ; Ceratopogonidae ; Ceratopogonidae - physiology ; Ceratopogonidae - virology ; Congenital defects ; Culex - virology ; Culicidae ; CVI Virologie ; CVI Virology ; Diptera ; Disease transmission ; Domestic animals ; Entomology ; Epidemics ; Epidemiology ; Epizootics ; Female ; Humans ; Infections ; Insect Vectors - physiology ; Insect Vectors - virology ; Laboratories ; Laboratorium voor Entomologie ; Laboratorium voor Virologie ; Laboratory of Entomology ; Laboratory of Virology ; Medicine and Health Sciences ; Mosquito Vectors - physiology ; Mosquito Vectors - virology ; Mosquitoes ; Neurological diseases ; Nigeria ; Orthobunyavirus - growth & development ; Orthobunyavirus - physiology ; Outbreaks ; Pathogenicity ; Pathogens ; PE&RC ; Penicillin ; Serology ; South Africa ; Species ; Transmission ; Tropical diseases ; Tropism ; Tropisms ; Vectors ; Veterinarians ; Veterinary surgeons ; Viral research ; Virologie ; Virology ; Virus-vector relationships ; Viruses ; West Nile virus ; Wildlife ; Zika virus ; Zoonoses</subject><ispartof>PLoS neglected tropical diseases, 2018-12, Vol.12 (12), p.e0006993-e0006993</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Möhlmann et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Möhlmann et al 2018 Möhlmann et al</rights><rights>Wageningen University & Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c675t-8878639393c69271e18a9606a744120df49625c69678f4a043793b9b8e5385b3</citedby><cites>FETCH-LOGICAL-c675t-8878639393c69271e18a9606a744120df49625c69678f4a043793b9b8e5385b3</cites><orcidid>0000-0002-0351-0407</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2262846610/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2262846610?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30532189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Fuehrer, Hans-Peter</contributor><creatorcontrib>Möhlmann, Tim W R</creatorcontrib><creatorcontrib>Oymans, Judith</creatorcontrib><creatorcontrib>Wichgers Schreur, Paul J</creatorcontrib><creatorcontrib>Koenraadt, Constantianus J M</creatorcontrib><creatorcontrib>Kortekaas, Jeroen</creatorcontrib><creatorcontrib>Vogels, Chantal B F</creatorcontrib><title>Vector competence of biting midges and mosquitoes for Shuni virus</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>Shuni virus (SHUV) is an orthobunyavirus that belongs to the Simbu serogroup. SHUV was isolated from diverse species of domesticated animals and wildlife, and is associated with neurological disease, abortions, and congenital malformations. Recently, SHUV caused outbreaks among ruminants in Israel, representing the first incursions outside the African continent. The isolation of SHUV from a febrile child in Nigeria and seroprevalence among veterinarians in South Africa suggests that the virus may have zoonotic potential as well. The high pathogenicity, extremely broad tropism, potential transmission via both biting midges and mosquitoes, and zoonotic features warrants prioritization of SHUV for further research. Additional knowledge is essential to accurately determine the risk for animal and human health, and to assess the risk of future epizootics and epidemics. To gain first insights into the potential involvement of arthropod vectors in SHUV transmission, we have investigated the ability of SHUV to infect and disseminate in laboratory-reared biting midges and mosquitoes.
Culicoides nubeculosus, C. sonorensis, Culex pipiens pipiens, and Aedes aegypti were orally exposed to SHUV by providing an infectious blood meal. Biting midges showed high infection rates of approximately 40-60%, whereas infection rates of mosquitoes were lower than 2%. SHUV successfully disseminated in both species of biting midges, but no evidence of transmission in orally exposed mosquitoes was found.
The results of this study show that different species of Culicoides biting midges are susceptible to infection and dissemination of SHUV, whereas the two mosquito species tested were found not to be susceptible.</description><subject>Aedes - virology</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Antibiotics</subject><subject>Aquatic insects</subject><subject>Biology and Life Sciences</subject><subject>Biting</subject><subject>Bunyaviridae Infections - transmission</subject><subject>Bunyaviridae Infections - virology</subject><subject>Bunyaviruses</subject><subject>Ceratopogonidae</subject><subject>Ceratopogonidae - physiology</subject><subject>Ceratopogonidae - virology</subject><subject>Congenital defects</subject><subject>Culex - virology</subject><subject>Culicidae</subject><subject>CVI Virologie</subject><subject>CVI Virology</subject><subject>Diptera</subject><subject>Disease transmission</subject><subject>Domestic animals</subject><subject>Entomology</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Epizootics</subject><subject>Female</subject><subject>Humans</subject><subject>Infections</subject><subject>Insect Vectors - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>NARCIS:Publications</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Möhlmann, Tim W R</au><au>Oymans, Judith</au><au>Wichgers Schreur, Paul J</au><au>Koenraadt, Constantianus J M</au><au>Kortekaas, Jeroen</au><au>Vogels, Chantal B F</au><au>Fuehrer, Hans-Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vector competence of biting midges and mosquitoes for Shuni virus</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>12</volume><issue>12</issue><spage>e0006993</spage><epage>e0006993</epage><pages>e0006993-e0006993</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>Shuni virus (SHUV) is an orthobunyavirus that belongs to the Simbu serogroup. SHUV was isolated from diverse species of domesticated animals and wildlife, and is associated with neurological disease, abortions, and congenital malformations. Recently, SHUV caused outbreaks among ruminants in Israel, representing the first incursions outside the African continent. The isolation of SHUV from a febrile child in Nigeria and seroprevalence among veterinarians in South Africa suggests that the virus may have zoonotic potential as well. The high pathogenicity, extremely broad tropism, potential transmission via both biting midges and mosquitoes, and zoonotic features warrants prioritization of SHUV for further research. Additional knowledge is essential to accurately determine the risk for animal and human health, and to assess the risk of future epizootics and epidemics. To gain first insights into the potential involvement of arthropod vectors in SHUV transmission, we have investigated the ability of SHUV to infect and disseminate in laboratory-reared biting midges and mosquitoes.
Culicoides nubeculosus, C. sonorensis, Culex pipiens pipiens, and Aedes aegypti were orally exposed to SHUV by providing an infectious blood meal. Biting midges showed high infection rates of approximately 40-60%, whereas infection rates of mosquitoes were lower than 2%. SHUV successfully disseminated in both species of biting midges, but no evidence of transmission in orally exposed mosquitoes was found.
The results of this study show that different species of Culicoides biting midges are susceptible to infection and dissemination of SHUV, whereas the two mosquito species tested were found not to be susceptible.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30532189</pmid><doi>10.1371/journal.pntd.0006993</doi><orcidid>https://orcid.org/0000-0002-0351-0407</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1935-2735 |
| ispartof | PLoS neglected tropical diseases, 2018-12, Vol.12 (12), p.e0006993-e0006993 |
| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
| recordid | cdi_plos_journals_2262846610 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | Aedes - virology Amino acids Animals Antibiotics Aquatic insects Biology and Life Sciences Biting Bunyaviridae Infections - transmission Bunyaviridae Infections - virology Bunyaviruses Ceratopogonidae Ceratopogonidae - physiology Ceratopogonidae - virology Congenital defects Culex - virology Culicidae CVI Virologie CVI Virology Diptera Disease transmission Domestic animals Entomology Epidemics Epidemiology Epizootics Female Humans Infections Insect Vectors - physiology Insect Vectors - virology Laboratories Laboratorium voor Entomologie Laboratorium voor Virologie Laboratory of Entomology Laboratory of Virology Medicine and Health Sciences Mosquito Vectors - physiology Mosquito Vectors - virology Mosquitoes Neurological diseases Nigeria Orthobunyavirus - growth & development Orthobunyavirus - physiology Outbreaks Pathogenicity Pathogens PE&RC Penicillin Serology South Africa Species Transmission Tropical diseases Tropism Tropisms Vectors Veterinarians Veterinary surgeons Viral research Virologie Virology Virus-vector relationships Viruses West Nile virus Wildlife Zika virus Zoonoses |
| title | Vector competence of biting midges and mosquitoes for Shuni virus |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T17%3A49%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vector%20competence%20of%20biting%20midges%20and%20mosquitoes%20for%20Shuni%20virus&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=M%C3%B6hlmann,%20Tim%20W%20R&rft.date=2018-12-01&rft.volume=12&rft.issue=12&rft.spage=e0006993&rft.epage=e0006993&rft.pages=e0006993-e0006993&rft.issn=1935-2735&rft.eissn=1935-2735&rft_id=info:doi/10.1371/journal.pntd.0006993&rft_dat=%3Cgale_plos_%3EA568167792%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c675t-8878639393c69271e18a9606a744120df49625c69678f4a043793b9b8e5385b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2262846610&rft_id=info:pmid/30532189&rft_galeid=A568167792&rfr_iscdi=true |