Characterizing Shigella species distribution and antimicrobial susceptibility to ciprofloxacin and nalidixic acid in Latin America between 2000-2015

Shigellosis is the second leading cause of diarrheal death globally. The global burden has been complicated by the emergence of Shigella strains resistant to first line antibiotic treatments such as ciprofloxacin. This study aims to describe the epidemiologic distribution of the most common Shigella...

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Bibliographic Details
Published in:PloS one 2019-08, Vol.14 (8), p.e0220445
Main Authors: Sati, Hatim F, Bruinsma, Nienke, Galas, Marcelo, Hsieh, Jenny, Sanhueza, Antonio, Ramon Pardo, Pilar, Espinal, Marcos A
Format: Article
Language:English
Subjects:
Acids
Anti-Bacterial Agents - pharmacology
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Antimicrobial resistance
Automation
Bacillary dysentery
Biology and Life Sciences
Biomedical laboratories
Breakpoints
Chemotherapy
Ciprofloxacin
Ciprofloxacin - pharmacology
Death
Diarrhea
Diffusion tests
Drug resistance
Drug Resistance, Bacterial - drug effects
Epidemiology
Health surveillance
Humans
Identification
Infectious diseases
Information management
Laboratories
Latin America
Medicine and Health Sciences
Methods
Microbial Sensitivity Tests
Nalidixic acid
Nalidixic Acid - pharmacology
Patient outcomes
Public health
R&D
Regression analysis
Research & development
Risk factors
Shigella
Shigella - drug effects
Shigella - isolation & purification
Shigellosis
Species
Trends
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Summary:Shigellosis is the second leading cause of diarrheal death globally. The global burden has been complicated by the emergence of Shigella strains resistant to first line antibiotic treatments such as ciprofloxacin. This study aims to describe the epidemiologic distribution of the most common Shigella species, and their antimicrobial susceptibility patterns to ciprofloxacin and nalidixic acid (NA) in Latin America. Laboratory data from 19 countries were obtained through the Latin American Network for Antimicrobial Resistance Surveillance (ReLAVRA) from 2000-2015. The Clinical Laboratory Standards Institute reduced susceptibility breakpoints for Enterobacteriaceae was used to interpret the disc diffusion tests for Shigella susceptibility to ciprofloxacin and NA. Negative binominal regression was used to analyze longitudinal trends of Shigella isolates antimicrobial susceptibility. 79,548 Shigella isolates were tested and reported between 2000-2015. The most common isolated species were S. flexneri (49%), and S. sonnei (28%). There was a steady increase in the proportion of S. sonnei isolates within the region(p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0220445