Relationship between the stage of osteoarthritis before and six months after tibial tuberosity advancement procedure in dogs

• Published in: PloS one 2019-08, Vol.14 (8), p.e0219849-e0219849
• Main Authors: Pinna, Stefania, Lanzi, Francesco, Cordella, Alessia, Diana, Alessia
• Format: Article
• Language: English
• Subjects: Animals; Anterior cruciate ligament; Arthritis; Biocompatibility; Biology and Life Sciences; Biomechanics; Care and treatment; Complications and side effects; Correlation analysis; Development and progression; Disease Progression; Dog diseases; Dogs; Knee; Ligaments; Male; Medical records; Medicine and Health Sciences; Osteoarthritis; Osteoarthritis - diagnostic imaging; Osteoarthritis - pathology; Osteoarthritis - surgery; Performance evaluation; Quality; Radiographs; Radiography; Statistical analysis; Surgery; Surgical outcomes; Tibia - surgery; Time Factors; Tomography, X-Ray Computed; Veterinary medicine; Veterinary surgery
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0219849

The present retrospective study evaluated the progression of osteoarthritis in stifle joints based on the radiographic grade of osteoarthritis (OA) scored in dogs with cranial cruciate ligament rupture. The aim of the study was to search for a correlation between the stage of radiographic osteoarthritis prior to surgery and the osteoarthritis progression occurring after the tibial tuberosity advancement (TTA) procedure. It was hypothesized that the procedure carried out in dogs in the early stages of OA could reduce the OA changes. A total of 190 X-ray images obtained from the medical records of 38 dogs were evaluated. The radiographic signs of osteoarthritis of 38 stifle joints were scored from 0 to 3 in 10 specific anatomic locations. The radiographs were divided into 4 groups based on the global scores: A) no-OA, B) mild-OA, C) moderate-OA, D) severe-OA; they were assessed prior to surgery, and 1, 2, 3 and 6 months post-operatively (T0, T1, T2, T3 and T6). There were no differences in osteoarthritis progression in Groups A and C at any time. Osteoarthritis changes from T0 to T6 were statistically significant in Group B. The OA changes in the anatomic locations were investigated. The most common anatomic sites for OA changes were the patella apex, the proximal and distal trochlear ridges, and the caudal aspect of the tibial plateau assessed before surgery. After surgery, the score increased in the first three locations in 10, 9 and 11 joints, respectively; instead, the progression of osteoarthritis in the caudal aspect of the tibial plateau occurred in 23 out of 38 stifle joints. The results indicated that the TTA procedure could be effective in slowing down the OA progression when carried out in the absence of or in the early stages of disease. Therefore, an early intervention may be suggested in clinical practice to obtain minimal or no progression 6 months postoperatively.