Dosage form suitability in vulnerable populations: A focus on paracetamol acceptability from infants to centenarians

Medicine acceptability is a multi-faceted concept driven by both product and user characteristics. Although a key factor for treatment effectiveness, especially in vulnerable populations, knowledge of those medicine features that best promote individual user acceptability remains fragmented. Focusin...

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Bibliographic Details
Published in:PloS one 2019-08, Vol.14 (8), p.e0221261-e0221261
Main Authors: Ruiz, Fabrice, Vallet, Thibault, Dufaÿ Wojcicki, Amélie, Belissa, Émilie, Fontan, Jean-Eudes, de Pontual, Loïc, Nathanson, Sylvie, Chevallier, Alain, Laribe-Caget, Sandra, Boudy, Vincent
Format: Article
Language:English
Subjects:
Acceptability
Acetaminophen
Acetaminophen - administration & dosage
Administration, Oral
Adolescent
Age Factors
Aged
Aged, 80 and over
Aging
Analgesics
Analysis
Biology and Life Sciences
Centenarians
Child
Child, Preschool
Clustering
Data analysis
Descriptive labeling
Disintegration
Dosage
Dosage and administration
Dosage Forms
Dose-response relationship
Drug dosages
Female
Formulations
Galenic pharmacology
Geriatrics
Health aspects
Hospitals
Humans
Infant
Infant, Newborn
Infants
Innovations
Life Sciences
Local population
Mapping
Medication Adherence
Medicine
Medicine and Health Sciences
Methods
Nursing homes
Older people
Oldest old people
Paracetamol
Patients
Pediatrics
People and Places
Pharmaceutical sciences
Pharmaceuticals
Pharmacology
Physical Sciences
Population
Populations
Powder
Product development
Prospective Studies
Swallowing
Tablets
Vulnerable Populations
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Description
Summary:Medicine acceptability is a multi-faceted concept driven by both product and user characteristics. Although a key factor for treatment effectiveness, especially in vulnerable populations, knowledge of those medicine features that best promote individual user acceptability remains fragmented. Focusing on paracetamol, this study has explored the appropriateness of pharmaceutical products in different dosage forms to achieve adequate patient acceptability from infants to centenarians. This observational, multicentre, prospective study was carried out in 10 hospitals, 8 nursing homes and over 150 community dispensaries. Observers reported several behaviours/events evaluating acceptability for 1016 different pharmaceutical product uses in paediatrics (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0221261