Contrast-enhanced Ultrasound in evaluating of angiogenesis and tumor staging of nasopharyngeal carcinoma in nude mice

To explore the use of Contrast-enhanced Ultrasound (CEUS) in evaluating angiogenesis in a xenograft nasopharyngeal carcinoma (NPC) model in nude mice and the evolution of CEUS parameters according to the growth of NPC. Nude mice were divided into three groups according to experiments conducted at va...

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Bibliographic Details
Published in:PloS one 2019-08, Vol.14 (8), p.e0221638
Main Authors: Liang, ShouJun, Gao, Yong, Liu, YaoLi, Qiu, ChengCheng, Chen, YanHao, Zhu, ShangYong
Format: Article
Language:English
Subjects:
Angiogenesis
Animal experimentation
Animals
Biology and Life Sciences
Cancer
Cancer staging
Cancer therapies
Carcinoma
Cell division
Cell Line, Tumor
Contrast Media - chemistry
Correlation
Correlation analysis
Correlation coefficient
Correlation coefficients
Diagnosis
Endothelial growth factors
Endothelium
Engineering and Technology
Flow velocity
Gene expression
Genetic aspects
Growth factors
Humans
Hypoxia
Implantation
Kidney - diagnostic imaging
Kidney - pathology
Kidneys
Laboratory animals
Mathematical models
Medical prognosis
Medicine and Health Sciences
Metastasis
Mice
Mice, Inbred BALB C
Mice, Nude
Microvessels - diagnostic imaging
Microvessels - pathology
Nasopharyngeal cancer
Nasopharyngeal carcinoma
Nasopharyngeal Carcinoma - blood supply
Nasopharyngeal Carcinoma - diagnostic imaging
Nasopharyngeal Carcinoma - pathology
Necrosis
Neoplasm Staging
Neovascularization, Pathologic - diagnostic imaging
NMR
Nuclear magnetic resonance
Parameters
Perfusion
Radiation therapy
Research and Analysis Methods
Risk factors
Statistical analysis
Studies
Throat cancer
Tumor Burden
Tumors
Ultrasonic imaging
Ultrasonography
Ultrasound
Vascular endothelial growth factor
Xenografts
Xenotransplantation
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Summary:To explore the use of Contrast-enhanced Ultrasound (CEUS) in evaluating angiogenesis in a xenograft nasopharyngeal carcinoma (NPC) model in nude mice and the evolution of CEUS parameters according to the growth of NPC. Nude mice were divided into three groups according to experiments conducted at various times from tumor implantation (8 mice/group; group A: 4 weeks from implantation; group B:6 weeks from implantation; group C:8 weeks from implantation). CNE-2 cells were transplanted in 24 nude mice and CEUS evaluations of the tumors were performed at 4, 6 or 8 weeks from implantation. CEUS parametric perfusion images and pathological findings were recorded. R version 3.4.4 software was used to analyze the CEUS parameters and pathological findings. One-way anova analysis indicated statistically significant differences among the three groups with the parameters of peak intensity (PI) (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0221638