Differential placental DNA methylation of VEGFA and LEP in small-for-gestational age fetuses with an abnormal cerebroplacental ratio

In Fetal Growth Restriction 'fetal programming' may take place via DNA methylation, which has implications for short-term and long-term health outcomes. Small-for-gestational age fetuses are considered fetal growth restricted, characterized by brain-sparing when fetal Doppler hemodynamics...

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Bibliographic Details
Published in:PloS one 2019-08, Vol.14 (8), p.e0221972-e0221972
Main Authors: Bekkering, Iris, Leeuwerke, Mariëtte, Tanis, Jozien C, Schoots, Mirthe H, Verkaik-Schakel, Rikst Nynke, Plösch, Torsten, Bilardo, Caterina M, Eijsink, Jasper J H, Bos, Arend F, Scherjon, Sicco A
Format: Article
Language:English
Subjects:
Adult
Age
Alleles
Angiogenesis
Biology and life sciences
Brain
Comparative analysis
CpG Islands
Deoxyribonucleic acid
Diabetes
DNA
DNA Methylation
Epigenesis, Genetic
Epigenetics
Erythropoietin
Female
Fetal development
Fetuses
Gene expression
Gene Expression Regulation
Genes
Genetic aspects
Gestational Age
Gynecology
Health
Hemodynamics
Humans
Hypoxia
Immunomodulation
Infant, Small for Gestational Age
LEP gene
Leptin
Leptin - genetics
Medicine and Health Sciences
Metabolism
Methylation
Neonatology
Obstetrics
Physical Sciences
Placenta
Placenta - metabolism
Pregnancy
Research and Analysis Methods
Small-for-gestational age
Ultrasonography, Prenatal
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - genetics
Young Adult
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Summary:In Fetal Growth Restriction 'fetal programming' may take place via DNA methylation, which has implications for short-term and long-term health outcomes. Small-for-gestational age fetuses are considered fetal growth restricted, characterized by brain-sparing when fetal Doppler hemodynamics are abnormal, expressed as a cerebroplacental ratio (CPR)
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0221972