Predicting the effects of deep brain stimulation using a reduced coupled oscillator model

• Published in: PLoS computational biology 2019-08, Vol.15 (8), p.e1006575-e1006575
• Main Authors: Weerasinghe, Gihan, Duchet, Benoit, Cagnan, Hayriye, Brown, Peter, Bick, Christian, Bogacz, Rafal
• Format: Article
• Language: English
• Subjects: Amplitudes; Analysis; Applied mathematics; Biology and Life Sciences; Brain; Brain - physiopathology; Brain stimulation; Computational Biology; Deep brain stimulation; Deep Brain Stimulation - methods; Deep Brain Stimulation - statistics & numerical data; Disorders; Essential Tremor - physiopathology; Essential Tremor - therapy; Humans; Influence; Mathematical models; Medicine and Health Sciences; Models, Neurological; Movement disorders; Neural oscillations; Neurodegenerative diseases; Neurogenesis; Neurological diseases; Neurons - physiology; Neurosciences; Oscillations; Oscillators; Parkinson Disease - physiopathology; Parkinson Disease - therapy; Parkinson's disease; Patients; Physical Sciences; Predictions; Research and Analysis Methods; Side effects; Signs and symptoms; Stimulation; Strategy; Tremor
• ISSN: 1553-7358; 1553-734X; 1553-7358
• DOI: 10.1371/journal.pcbi.1006575

Deep brain stimulation (DBS) is known to be an effective treatment for a variety of neurological disorders, including Parkinson's disease and essential tremor (ET). At present, it involves administering a train of pulses with constant frequency via electrodes implanted into the brain. New 'closed-loop' approaches involve delivering stimulation according to the ongoing symptoms or brain activity and have the potential to provide improvements in terms of efficiency, efficacy and reduction of side effects. The success of closed-loop DBS depends on being able to devise a stimulation strategy that minimizes oscillations in neural activity associated with symptoms of motor disorders. A useful stepping stone towards this is to construct a mathematical model, which can describe how the brain oscillations should change when stimulation is applied at a particular state of the system. Our work focuses on the use of coupled oscillators to represent neurons in areas generating pathological oscillations. Using a reduced form of the Kuramoto model, we analyse how a patient should respond to stimulation when neural oscillations have a given phase and amplitude, provided a number of conditions are satisfied. For such patients, we predict that the best stimulation strategy should be phase specific but also that stimulation should have a greater effect if applied when the amplitude of brain oscillations is lower. We compare this surprising prediction with data obtained from ET patients. In light of our predictions, we also propose a new hybrid strategy which effectively combines two of the closed-loop strategies found in the literature, namely phase-locked and adaptive DBS.