Antibacterial activity of varying UMF-graded Manuka honeys

Honey has been used as a traditional remedy for skin and soft tissue infections due to its ability to promote wound healing. Manuka honey is recognized for its unusually abundant content of the antibacterial compound, methylglyoxal (MGO). The Unique Manuka Factor (UMF) grading system reflects the MG...

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Bibliographic Details
Published in:PloS one 2019-10, Vol.14 (10), p.e0224495-e0224495
Main Authors: Girma, Alodia, Seo, Wonjae, She, Rosemary C
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Antibacterial agents
Antibacterial materials
Antibiotics
Antimicrobial activity
Antimicrobial agents
Bacteria
Bacteria - drug effects
Biology and Life Sciences
Care and treatment
Cell division
Clinical trials
Drug resistance
Drug Resistance, Multiple - drug effects
Enterobacteriaceae
Gram-negative bacteria
Honey
Honey - analysis
Infection
Medical research
Medicine and Health Sciences
Methicillin
Microbial drug resistance
Microbial Sensitivity Tests
Microorganisms
Minimum inhibitory concentration
Multidrug resistance
Nonprescription drugs
Pathogenic microorganisms
Pathology
Phytochemicals
Pseudomonas aeruginosa
Pyruvaldehyde
Pyruvaldehyde - analysis
Pyruvaldehyde - pharmacology
Skin
Soft tissues
Staphylococcus aureus
Staphylococcus infections
Wound care
Wound healing
Wounds
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Summary:Honey has been used as a traditional remedy for skin and soft tissue infections due to its ability to promote wound healing. Manuka honey is recognized for its unusually abundant content of the antibacterial compound, methylglyoxal (MGO). The Unique Manuka Factor (UMF) grading system reflects the MGO concentration in Manuka honey sold commercially. Our objective was to observe if UMF values correlated with the antibacterial activity of Manuka honey against a variety of pathogens purchased over the counter. The antibacterial effect of Manuka honey with UMF values of 5+, 10+, and 15+ from the same manufacturer was assessed by the broth microdilution method. Minimum inhibitory concentration (MIC) values were determined against 128 isolates from wound cultures representing gram-positive, gram-negative, drug-susceptible, and multi-drug resistant (MDR) organisms. Lower MICs were observed with UMF 5+ honey for staphylococci (n = 73, including 25 methicillin-resistant S. aureus) and Pseudomonas aeruginosa (n = 22, including 10 MDR) compared to UMF 10+ honey (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0224495