Elevated Ki-67 (MIB-1) expression as an independent predictor for unfavorable pathologic outcomes and biochemical recurrence after radical prostatectomy in patients with localized prostate cancer: A propensity score matched study

Ki-67 is known to be useful in estimating the fraction of proliferation tumor cells in various malignancies. We tried to investigate clinical association of Ki-67 (MIB-1) expression with the oncological outcomes in patients with localized prostate cancer (PCa) after the radical prostatectomy (RP). W...

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Published in:PloS one 2019-11, Vol.14 (11), p.e0224671-e0224671
Main Authors: Byun, Seok-Soo, Lee, Minseung, Hong, Sung Kyu, Lee, Hakmin
Format: Article
Language:English
Subjects:
2-Methylisoborneol
Aged
Analysis
Antigens
Biochemistry
Biology and Life Sciences
Biomarkers
Breast cancer
Cancer patients
Cancer research
Cancer surgery
Cancer therapies
Care and treatment
Cell proliferation
Humans
Kaplan-Meier Estimate
Ki-67 Antigen - metabolism
Male
Medical prognosis
Medicine and Health Sciences
Metastasis
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local - metabolism
Neoplasm Recurrence, Local - pathology
Patient outcomes
Physical Sciences
Prognosis
Propensity Score
Proportional Hazards Models
Prostate cancer
Prostatectomy
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
Radiation therapy
Recurrence (Disease)
Regression analysis
Research and Analysis Methods
Review boards
Seminal vesicle
Statistical models
Surgery
Survival
Treatment Outcome
Tumor cells
Tumors
Urological surgery
Urology
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Lee, Minseung
Hong, Sung Kyu
Lee, Hakmin
description Ki-67 is known to be useful in estimating the fraction of proliferation tumor cells in various malignancies. We tried to investigate clinical association of Ki-67 (MIB-1) expression with the oncological outcomes in patients with localized prostate cancer (PCa) after the radical prostatectomy (RP). We retrospectively analyzed the data of 1,561 patients who underwent RP for localized PCa. According to the propensity score having Ki-67 expression, 183 patients with positive Ki-67 expression were matched to 549 patients without Ki-67 expression. By using multivariate Cox-proportional hazards models and logistic regression tests, the prognostic value of each variable was tested. After propensity score matching, positive Ki-67 group showed significant worse clinical characteristics and pathologic outcomes than negative Ki-67 group. The multivariate analysis showed that the Ki-67 expression was significantly associated with several adverse pathologic outcomes including higher pathologic stage (p = 0.006), higher grade group (p = 0.005), seminal vesicle invasion (p = 0.036), and positive surgical margin (p = 0.025). The group with Ki-67 expression showed significant worse biochemical recurrence-free survival (p
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We tried to investigate clinical association of Ki-67 (MIB-1) expression with the oncological outcomes in patients with localized prostate cancer (PCa) after the radical prostatectomy (RP). We retrospectively analyzed the data of 1,561 patients who underwent RP for localized PCa. According to the propensity score having Ki-67 expression, 183 patients with positive Ki-67 expression were matched to 549 patients without Ki-67 expression. By using multivariate Cox-proportional hazards models and logistic regression tests, the prognostic value of each variable was tested. After propensity score matching, positive Ki-67 group showed significant worse clinical characteristics and pathologic outcomes than negative Ki-67 group. The multivariate analysis showed that the Ki-67 expression was significantly associated with several adverse pathologic outcomes including higher pathologic stage (p = 0.006), higher grade group (p = 0.005), seminal vesicle invasion (p = 0.036), and positive surgical margin (p = 0.025). The group with Ki-67 expression showed significant worse biochemical recurrence-free survival (p&lt;0.001) than negative Ki-67 group. Subsequent multivariate Cox analyses showed that Ki-67 was independent predictor for BCR after RP (HR 1.549, 95% CI 1.187-2.021, p = 0.001). In our study, high Ki-67 expression was significantly related with adverse pathological and finally with worse biochemical recurrence-free survival. Further studies are needed to validate the prognostic value of Ki-67 more exactly in PCa patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31697718</pmid><doi>10.1371/journal.pone.0224671</doi><orcidid>https://orcid.org/0000-0002-1247-9958</orcidid><oa>free_for_read</oa></addata></record>
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subjects 2-Methylisoborneol
Aged
Analysis
Antigens
Biochemistry
Biology and Life Sciences
Biomarkers
Breast cancer
Cancer patients
Cancer research
Cancer surgery
Cancer therapies
Care and treatment
Cell proliferation
Humans
Kaplan-Meier Estimate
Ki-67 Antigen - metabolism
Male
Medical prognosis
Medicine and Health Sciences
Metastasis
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local - metabolism
Neoplasm Recurrence, Local - pathology
Patient outcomes
Physical Sciences
Prognosis
Propensity Score
Proportional Hazards Models
Prostate cancer
Prostatectomy
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
Radiation therapy
Recurrence (Disease)
Regression analysis
Research and Analysis Methods
Review boards
Seminal vesicle
Statistical models
Surgery
Survival
Treatment Outcome
Tumor cells
Tumors
Urological surgery
Urology
title Elevated Ki-67 (MIB-1) expression as an independent predictor for unfavorable pathologic outcomes and biochemical recurrence after radical prostatectomy in patients with localized prostate cancer: A propensity score matched study
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T17%3A56%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Elevated%20Ki-67%20(MIB-1)%20expression%20as%20an%20independent%20predictor%20for%20unfavorable%20pathologic%20outcomes%20and%20biochemical%20recurrence%20after%20radical%20prostatectomy%20in%20patients%20with%20localized%20prostate%20cancer:%20A%20propensity%20score%20matched%20study&rft.jtitle=PloS%20one&rft.au=Byun,%20Seok-Soo&rft.date=2019-11-07&rft.volume=14&rft.issue=11&rft.spage=e0224671&rft.epage=e0224671&rft.pages=e0224671-e0224671&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0224671&rft_dat=%3Cgale_plos_%3EA605081713%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c593t-35ecf29b483afe3904495a389641a9ccc2ef36a6a2cd38a1b752f3ab33429ca73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2312799179&rft_id=info:pmid/31697718&rft_galeid=A605081713&rfr_iscdi=true