Application of CPI cutoff value based on parentage testing of duos and trios typed by four autosomal kits

In this study, we analyzed the application of four autosomal kits and the sensitivity of the combined paternity index (CPI) cutoff value (CPI≥10000) in parentage testing. First, 1442 real trios and 803 real duos were tested using the Goldeneye 25A kit. The Goldeneye 25A kit covers the autosomal shor...

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Published in:PloS one 2019-11, Vol.14 (11), p.e0225174-e0225174
Main Authors: Gao, Hongmei, Wang, Chang, Zhang, Ruxia, Wu, Hanyang, Sun, Shanhui, Xiao, Dongjie, Wang, Yunshan, Zhang, Maoxiu
Format: Article
Language:English
Subjects:
Aquatic birds
Biology and Life Sciences
Chromosomes
Deoxyribonucleic acid
DNA
Fathers
Female
Forensic Genetics - methods
Gene mutation
Genetic Loci
Humans
Laboratories
Male
Medicine and Health Sciences
Microsatellite Repeats
Mutation
Paternity
People and Places
Research and analysis methods
Sensitivity analysis
Short tandem repeats
Social Sciences
Values
X chromosomes
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container_title PloS one
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creator Gao, Hongmei
Wang, Chang
Zhang, Ruxia
Wu, Hanyang
Sun, Shanhui
Xiao, Dongjie
Wang, Yunshan
Zhang, Maoxiu
description In this study, we analyzed the application of four autosomal kits and the sensitivity of the combined paternity index (CPI) cutoff value (CPI≥10000) in parentage testing. First, 1442 real trios and 803 real duos were tested using the Goldeneye 25A kit. The Goldeneye 25A kit covers the autosomal short tandem repeat (STR) loci of the other three kits, so we calculated the CPI value of every case for the four kits. Second, three complex close relative kinship cases were also analyzed to evaluate the application of the CPI cutoff value. The CPI values of all trio cases were higher than 10000 using the four kits; the CPI values of all duo cases were higher than 10000 using the Goldeneye 25A kit; and the CPI values of a portion of the duo cases were lower than 10000 using the other three kits. In the three complex close relative cases, the alleged father or mother was not excluded using 40 autosomal STRs. Adding X chromosome short tandem repeats (X-STR) and samples of biological fathers or mothers, the conclusions were confirmed. The four kits were adequate to draw conclusions in the trio cases; the Goldeneye 25A Kit was adequate to draw conclusions in the duo cases; and the other three kits were not sufficient for a portion of the duo cases. The CPI cutoff value was sensitive for real trio and duo cases. In complex close relative kinship cases, high CPI values may result in false conclusions.
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First, 1442 real trios and 803 real duos were tested using the Goldeneye 25A kit. The Goldeneye 25A kit covers the autosomal short tandem repeat (STR) loci of the other three kits, so we calculated the CPI value of every case for the four kits. Second, three complex close relative kinship cases were also analyzed to evaluate the application of the CPI cutoff value. The CPI values of all trio cases were higher than 10000 using the four kits; the CPI values of all duo cases were higher than 10000 using the Goldeneye 25A kit; and the CPI values of a portion of the duo cases were lower than 10000 using the other three kits. In the three complex close relative cases, the alleged father or mother was not excluded using 40 autosomal STRs. Adding X chromosome short tandem repeats (X-STR) and samples of biological fathers or mothers, the conclusions were confirmed. The four kits were adequate to draw conclusions in the trio cases; the Goldeneye 25A Kit was adequate to draw conclusions in the duo cases; and the other three kits were not sufficient for a portion of the duo cases. The CPI cutoff value was sensitive for real trio and duo cases. 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source Open Access: PubMed Central; Publicly Available Content Database
subjects Aquatic birds
Biology and Life Sciences
Chromosomes
Deoxyribonucleic acid
DNA
Fathers
Female
Forensic Genetics - methods
Gene mutation
Genetic Loci
Humans
Laboratories
Male
Medicine and Health Sciences
Microsatellite Repeats
Mutation
Paternity
People and Places
Research and analysis methods
Sensitivity analysis
Short tandem repeats
Social Sciences
Values
X chromosomes
title Application of CPI cutoff value based on parentage testing of duos and trios typed by four autosomal kits
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