Surveillance to maintain the sensitivity of genotype-based antibiotic resistance diagnostics

The sensitivity of genotype-based diagnostics that predict antimicrobial susceptibility is limited by the extent to which they detect genes and alleles that lead to resistance. As novel resistance variants are expected to emerge, such sensitivity is expected to decline unless the new variants are de...

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Bibliographic Details
Published in:PLoS biology 2019-11, Vol.17 (11), p.e3000547-e3000547
Main Authors: Hicks, Allison L, Kissler, Stephen M, Lipsitch, Marc, Grad, Yonatan H
Format: Article
Language:English
Subjects:
Antibiotic resistance
Antibiotics
Antimicrobial agents
Biology and Life Sciences
Diagnostic systems
Drug resistance
Drug resistance in microorganisms
Drug Resistance, Bacterial - genetics
Drug Resistance, Microbial - genetics
Epidemiological Monitoring
Failure
Genetic aspects
Genetic Markers
Genotype
Genotype & phenotype
Genotypes
Imipenem
Immunology
Infectious diseases
Medicine and Health Sciences
Microbial Sensitivity Tests
Mutation
Pathogens
Penicillin
Proteins
Public health
Sensitivity
Short Reports
Surveillance
Survival analysis
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Summary:The sensitivity of genotype-based diagnostics that predict antimicrobial susceptibility is limited by the extent to which they detect genes and alleles that lead to resistance. As novel resistance variants are expected to emerge, such sensitivity is expected to decline unless the new variants are detected and incorporated into the diagnostic. Here, we present a mathematical framework to define how many diagnostic failures may be expected under varying surveillance regimes and thus quantify the surveillance needed to maintain the sensitivity of genotype-based diagnostics.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.3000547