Mouse protein coding diversity: What's left to discover?

For over a century, mice have been used to model human disease, leading to many fundamental discoveries about mammalian biology and the development of new therapies. Mouse genetics research has been further catalysed by a plethora of genomic resources developed in the last 20 years, including the ge...

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Bibliographic Details
Published in:PLoS genetics 2019-11, Vol.15 (11), p.e1008446-e1008446
Main Authors: Lilue, Jingtao, Shivalikanjli, Anu, Adams, David J, Keane, Thomas M
Format: Article
Language:English
Subjects:
Analysis
Animal behavior
Animals
Animals, Inbred Strains - genetics
Artificial chromosomes
Bioinformatics
Biology and Life Sciences
Biomedical research
Chromosome Mapping
Genes
Genetic research
Genetics
Genome - genetics
Genomes
Genomics
Haplotypes
House mouse
Humans
Immune system
Inbreeding
Laboratories
Mice
Molecular biology
Nucleotide sequence
Phenotype
Proteins
Research and Analysis Methods
Review
Rodents
Zebrafish
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Summary:For over a century, mice have been used to model human disease, leading to many fundamental discoveries about mammalian biology and the development of new therapies. Mouse genetics research has been further catalysed by a plethora of genomic resources developed in the last 20 years, including the genome sequence of C57BL/6J and more recently the first draft reference genomes for 16 additional laboratory strains. Collectively, the comparison of these genomes highlights the extreme diversity that exists at loci associated with the immune system, pathogen response, and key sensory functions, which form the foundation for dissecting phenotypic traits in vivo. We review the current status of the mouse genome across the diversity of the mouse lineage and discuss the value of mice to understanding human disease.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1008446