Comparison of Monocyte Distribution Width (MDW) and Procalcitonin for early recognition of sepsis

We carried out a prospective observational study to evaluate whether Monocyte Distribution Width (MDW) may play a role in identifying patients with sepsis in comparison with Procalcitonin (PCT). We prospectively enrolled all consecutive patients hospitalized at the Infectious Diseases Unit of Pescar...

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Bibliographic Details
Published in:PloS one 2020-01, Vol.15 (1), p.e0227300-e0227300
Main Authors: Polilli, Ennio, Sozio, Federica, Frattari, Antonella, Persichitti, Laura, Sensi, Marina, Posata, Raffaella, Di Gregorio, Marco, Sciacca, Antonina, Flacco, Maria Elena, Manzoli, Lamberto, Di Iorio, Giancarlo, Parruti, Giustino
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bacterial diseases
Bacterial infections
Biology and Life Sciences
Blood
Blood diseases
Blood platelets
Cell Size
Chronic illnesses
Chronic obstructive pulmonary disease
Comorbidity
Continuity (mathematics)
Demographics
Early Diagnosis
Family medical history
Female
Hemoglobin
Hospitalization
Hospitals
Humans
Infections
Infectious diseases
Intensive care
Laboratories
Leukocyte Count
Male
Males
Medicine and Health Sciences
Middle Aged
Monocytes
Monocytes - pathology
Neutrophils
Pathology
Patients
Procalcitonin
Procalcitonin - blood
Prognosis
Prospective Studies
ROC Curve
Sepsis
Shock, Septic - complications
Shock, Septic - diagnosis
Staphylococcal Infections - complications
Staphylococcal Infections - diagnosis
Staphylococcus - isolation & purification
Studies
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Summary:We carried out a prospective observational study to evaluate whether Monocyte Distribution Width (MDW) may play a role in identifying patients with sepsis in comparison with Procalcitonin (PCT). We prospectively enrolled all consecutive patients hospitalized at the Infectious Diseases Unit of Pescara General Hospital for bacterial infection or sepsis. MDW values were collected for all patients. Clinical characteristics, demographic data, past and present medical history, microbiological results, PCT, as well as neutrophil and monocytes indices at entry were compared in the 2 groups. Two-hundred-sixty patients were enrolled, 63.5% males, aged 59.1±19.5 years. Sepsis was diagnosed in 105 (40.4%); in 60 (57.1%) at least 1 microorganism was isolated from blood cultures. In multivariate models, MDW as a continuous variable (OR:1.57 for each unit increase; 95%CI: 1.31-1.87, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0227300