Polymer-fiber-coupled field-effect sensors for label-free deep brain recordings

Electrical recording permits direct readout of neural activity but offers limited ability to correlate it to the network topography. On the other hand, optical imaging reveals the architecture of neural circuits, but relies on bulky optics and fluorescent reporters whose signals are attenuated by th...

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Bibliographic Details
Published in:PloS one 2020-01, Vol.15 (1), p.e0228076-e0228076
Main Authors: Guo, Yuanyuan, Werner, Carl F, Canales, Andres, Yu, Li, Jia, Xiaoting, Anikeeva, Polina, Yoshinobu, Tatsuo
Format: Article
Language:English
Subjects:
Animals
Biology and Life Sciences
Biomedical engineering
Brain
Brain - physiology
Brain research
Bundles
Computer engineering
Electrodes
Electrolytes
Electrophysiological Phenomena
Engineering and Technology
Fiber optics
Fluorescence
Hydrogen-Ion Concentration
Journalists
Laboratories
Light
Light beams
Male
Mapping
Materials science
Medicine and Health Sciences
Mice, Inbred C57BL
Neural circuitry
Neural networks
Neuroimaging
Optical fibers
Optical waveguides
Optics
Photoelectric effect
Photoelectric emission
Physical Sciences
Polycarboxylate Cement - chemistry
Polymer industry
Polymers
Polymers - chemistry
Polymethyl Methacrylate - chemistry
Prostheses and implants
Raster scanning
Research and Analysis Methods
Semiconductors
Sensors
Silicon nitride
Silicon wafers
Technology
Temperature
Waveguides
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Description
Summary:Electrical recording permits direct readout of neural activity but offers limited ability to correlate it to the network topography. On the other hand, optical imaging reveals the architecture of neural circuits, but relies on bulky optics and fluorescent reporters whose signals are attenuated by the brain tissue. Here we introduce implantable devices to record brain activities based on the field effect, which can be further extended with capability of label-free electrophysiological mapping. Such devices reply on light-addressable potentiometric sensors (LAPS) coupled to polymer fibers with integrated electrodes and optical waveguide bundles. The LAPS utilizes the field effect to convert electrophysiological activity into regional carrier redistribution, and the neural activity is read out in a spatially resolved manner as a photocurrent induced by a modulated light beam. Spatially resolved photocurrent recordings were achieved by illuminating different pixels within the fiber bundles. These devices were applied to record local field potentials in the mouse hippocampus. In conjunction with the raster-scanning via the single modulated beam, this technology may enable fast label-free imaging of neural activity in deep brain regions.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0228076