Expression of the muscle-associated gene MYF6 in hairy cell leukemia

Hairy cell leukemia (HCL) is a purine analog-responsive B-cell malignancy containing the BRAF V600E mutation, expressing CD22, CD11c, CD103, tartrate resistant acid phosphatase (TRAP) CD25, CD123, and annexin 1A. BRAF V600E and the latter 4 markers are usually absent in the more aggressive and chemo...

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Published in:PloS one 2020-02, Vol.15 (2), p.e0227586-e0227586
Main Authors: Arons, Evgeny, Zhou, Hong, Sokolsky, Mark, Gorelik, Daniel, Potocka, Katherine, Davies, Sarah, Fykes, Erin, Still, Katherine, Edelman, Daniel C, Wang, Yonghong, Meltzer, Paul S, Raffeld, Mark, Wiestner, Adrian, Xi, Liqiang, Wang, Hao-Wei, Stetler-Stevenson, Maryalice, Yuan, Constance, Kreitman, Robert J
Format: Article
Language:English
Subjects:
Acid phosphatase
Acid phosphatase (tartrate-resistant)
Acid resistance
Adult
Aged
Alkaloids
B cells
Biology and Life Sciences
Biomarkers
Biotechnology industries
Blood
Blood donation
Blood donors
Cancer
Cancer genetics
CD103 antigen
CD11c antigen
CD123 antigen
CD22 antigen
CD25 antigen
Chronic lymphocytic leukemia
Consent
DNA Methylation - genetics
DNA microarrays
EDTA
Female
Flow cytometry
Gene expression
Gene Expression Profiling
Gene Expression Regulation, Leukemic
Gene mutation
Genes
Genetic aspects
Hairy cell leukemia
Humans
Laboratories
Leukemia
Leukemia, Hairy Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Limit of Detection
Lymphatic leukemia
Lymphocytes B
Lymphocytic leukemia
Lymphoma
Lymphomas
Male
Malignancy
Mantle cell lymphoma
Medical prognosis
Medicine and Health Sciences
Middle Aged
Molecular biology
Muscles
Muscles - metabolism
Musculoskeletal system
Mutation
Myogenic Regulatory Factors - genetics
Myogenic Regulatory Factors - metabolism
Neoplasm, Residual - genetics
Neoplasm, Residual - pathology
Pathology
Phosphatases
Polymerase chain reaction
Probes
Research and Analysis Methods
Time
Tumors
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Summary:Hairy cell leukemia (HCL) is a purine analog-responsive B-cell malignancy containing the BRAF V600E mutation, expressing CD22, CD11c, CD103, tartrate resistant acid phosphatase (TRAP) CD25, CD123, and annexin 1A. BRAF V600E and the latter 4 markers are usually absent in the more aggressive and chemoresistant variant HCLv. To evaluate differences between HCL and HCLv, expression microarrays comparing HCL with HCLv were performed for 24694 genes using 47323 probes. Microarray data from 35 HCL and 27 HCLv purified samples showed the greatest HCL-HCLv difference in the muscle-associated gene MYF6, expressed by its 2 probes 18.5- and 10.8-fold higher in HCL than HCLv (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0227586