High-risk human papillomavirus prevalence in self-collected cervicovaginal specimens from human immunodeficiency virus (HIV)-negative women and women living with HIV living in Botswana

The prevalence of high-risk human papillomavirus (hrHPV) is poorly described overall and in women living with HIV (WLWH) and HIV-negative women living in Botswana, a high HIV and cervical cancer-burden country. We conducted a pilot study of self-collection and high-risk HPV testing for cervical scre...

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Bibliographic Details
Published in:PloS one 2020-02, Vol.15 (2), p.e0229086-e0229086
Main Authors: Castle, Philip E, Varallo, John E, Bertram, Margaret Mary, Ratshaa, Bakgaki, Kitheka, Moses, Rammipi, Kereng
Format: Article
Language:English
Subjects:
Abnormalities
Adult
Age
Age groups
Biology and life sciences
Botswana - epidemiology
Cervical cancer
Cervix
Clinics
Consent
Cryotherapy
Early Detection of Cancer
Female
Health care facilities
Health facilities
Health risks
HIV
HIV Infections - epidemiology
Human immunodeficiency virus
Human papillomavirus
Humans
Infections
Medical screening
Medicine and Health Sciences
Middle Aged
Nurses
Odds Ratio
Papillomavirus Infections - epidemiology
People and Places
Prevalence
Public health
Risk
Risk groups
Uterine Cervical Neoplasms - epidemiology
Viruses
Womens health
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Summary:The prevalence of high-risk human papillomavirus (hrHPV) is poorly described overall and in women living with HIV (WLWH) and HIV-negative women living in Botswana, a high HIV and cervical cancer-burden country. We conducted a pilot study of self-collection and high-risk HPV testing for cervical screening, from which data on HPV prevalence was available. From five health facilities in the Kweneng East District, 1,022 women aged 30-49 years were enrolled to self-collect their cervicovaginal specimen for hrHPV testing by the Xpert HPV Test (Cepheid, Sunnyvale, CA, USA). Crude and age group-adjusted hrHPV prevalence by HIV status were calculated, and the relationship of hrHPV risk groups HPV16>HPV18/45>other hrHPV types) to the presence and severity of visible lesions. Of the 1,022 women enrolled, 1,019 (99.7%), 570 WLWH and 449 HIV-negative women, had hrHPV testing results. Crude hrHPV prevalences were 25.2% (95%CI = 21.2-29.4%) for HIV-negative women and 40.4% (95%CI = 36.3-44.5%) for WLWH. Age group-adjusted hrHPV prevalences were 23.7% (95%CI = 19.9-27.9%) for HIV-negative women and 41.3% (95%CI = 37.2-45.4%) for WLWH. Age group-adjusted prevalences of HPV16 (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0229086