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The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders

The genetic architecture of the small and isolated Greenlandic population is advantageous for identification of novel genetic variants associated with cardio-metabolic traits. We aimed to identify genetic loci associated with body mass index (BMI), to expand the knowledge of the genetic and biologic...

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Published in:PLoS genetics 2020-01, Vol.16 (1), p.e1008544-e1008544
Main Authors: Andersen, Mette K, Jørsboe, Emil, Skotte, Line, Hanghøj, Kristian, Sandholt, Camilla H, Moltke, Ida, Grarup, Niels, Kern, Timo, Mahendran, Yuvaraj, Søborg, Bolette, Bjerregaard, Peter, Larsen, Christina V L, Dahl-Petersen, Inger K, Tiwari, Hemant K, Feenstra, Bjarke, Koch, Anders, Wiener, Howard W, Hopkins, Scarlett E, Pedersen, Oluf, Melbye, Mads, Boyer, Bert B, Jørgensen, Marit E, Albrechtsen, Anders, Hansen, Torben
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Language:English
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Summary:The genetic architecture of the small and isolated Greenlandic population is advantageous for identification of novel genetic variants associated with cardio-metabolic traits. We aimed to identify genetic loci associated with body mass index (BMI), to expand the knowledge of the genetic and biological mechanisms underlying obesity. Stage 1 BMI-association analyses were performed in 4,626 Greenlanders. Stage 2 replication and meta-analysis were performed in additional cohorts comprising 1,058 Yup'ik Alaska Native people, and 1,529 Greenlanders. Obesity-related traits were assessed in the stage 1 study population. We identified a common variant on chromosome 11, rs4936356, where the derived G-allele had a frequency of 24% in the stage 1 study population. The derived allele was genome-wide significantly associated with lower BMI (beta (SE), -0.14 SD (0.03), p = 3.2x10-8), corresponding to 0.64 kg/m2 lower BMI per G allele in the stage 1 study population. We observed a similar effect in the Yup'ik cohort (-0.09 SD, p = 0.038), and a non-significant effect in the same direction in the independent Greenlandic stage 2 cohort (-0.03 SD, p = 0.514). The association remained genome-wide significant in meta-analysis of the Arctic cohorts (-0.10 SD (0.02), p = 4.7x10-8). Moreover, the variant was associated with a leaner body type (weight, -1.68 (0.37) kg; waist circumference, -1.52 (0.33) cm; hip circumference, -0.85 (0.24) cm; lean mass, -0.84 (0.19) kg; fat mass and percent, -1.66 (0.33) kg and -1.39 (0.27) %; visceral adipose tissue, -0.30 (0.07) cm; subcutaneous adipose tissue, -0.16 (0.05) cm, all p
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1008544