Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging

Irisin concentrations are decreased in subjects with overt diabetes and upregulated in those with obesity or impaired fasting glucose. However, gender-balanced data in older populations, in whom risk factors commonly culminate in overt cardiovascular disease, are scarce. We assessed in non-diabetic...

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Bibliographic Details
Published in:PloS one 2020-02, Vol.15 (2), p.e0229152-e0229152
Main Authors: Campolo, Jonica, Corradi, Ettore, Rizzardi, Alice, Parolini, Marina, Dellanoce, Cinzia, Di Guglielmo, Maria Luisa, Tarlarini, Patrizia, Cattaneo, Marina, Trivella, Maria Giovanna, De Maria, Renata
Format: Article
Language:English
Subjects:
Adipose tissue
Aged
Aging
Aging - blood
Aging - metabolism
Biology and Life Sciences
Biomarkers - metabolism
Body composition
Body fat
Body mass
Body mass index
Body size
Cardiovascular diseases
Diabetes
Diabetes mellitus
Diabetics
Diseases
EDTA
Energy
Enzyme-linked immunosorbent assay
European Continental Ancestry Group
Exercise
Fasting
Fatty liver
Female
Fibronectins - metabolism
Gender
Gender aspects
Gerontology
Glucose
Humans
Insulin
Insulin resistance
Laboratories
Levels
Lipids
Liver
Liver diseases
Male
Markers
Medical research
Medicine and Health Sciences
Men
Metabolism
Middle age
Middle Aged
Nutrition research
Obesity
Obesity - blood
Obesity - metabolism
Obesity - physiopathology
Physiology
Plethysmography
Questionnaires
Risk analysis
Risk factors
Sex Characteristics
Sex differences
Triglycerides
Type 2 diabetes
Weight control
Women
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Summary:Irisin concentrations are decreased in subjects with overt diabetes and upregulated in those with obesity or impaired fasting glucose. However, gender-balanced data in older populations, in whom risk factors commonly culminate in overt cardiovascular disease, are scarce. We assessed in non-diabetic Caucasian subjects with stage I-II obesity in the early aging range (50 to 70 years), the relationship between irisin, body composition and markers of metabolic derangement by gender. In 60 (31 women, 29 men) non-diabetics with a body mass index ≥30 - ≤40 kg/m2, we measured anthropometrics and body composition (Air Displacement Plethysmography). We assayed lipid and glucose profile by routine methods, plasma irisin by ELISA and measured insulin resistance by the HOMA index. Irisin levels were higher in women than in men (161 [105-198]) vs 83 [33-115] ng/ml, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0229152