Fetuin-A in Metabolic syndrome: A systematic review and meta-analysis

Fetuin-A has been associated with the progression of metabolic syndrome, but previous studies found inconsistent results on the relationship between metabolic syndrome and the concentration of fetuin-A. The aim of this study was to perform a meta-analysis to summarize previous findings on this relat...

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Bibliographic Details
Published in:PloS one 2020-03, Vol.15 (3), p.e0229776-e0229776
Main Authors: Pan, Xiongfeng, Wen, Shi Wu, Bestman, Prince L, Kaminga, Atipatsa C, Acheampong, Kwabena, Liu, Aizhong
Format: Article
Language:English
Subjects:
Analysis
Biological markers
Biology and Life Sciences
Biomarkers
Confidence intervals
Insulin resistance
Kinases
Medical research
Medicine and Health Sciences
Meta-analysis
Metabolic disorders
Metabolic syndrome
Novels
Physical Sciences
Research and Analysis Methods
Risk analysis
Risk factors
Studies
Tumor necrosis factor-TNF
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Summary:Fetuin-A has been associated with the progression of metabolic syndrome, but previous studies found inconsistent results on the relationship between metabolic syndrome and the concentration of fetuin-A. The aim of this study was to perform a meta-analysis to summarize previous findings on this relationship. This study was registered with the International Prospective Register of Systematic Reviews PROSPERO (CRD42019129566). Studies examining the relationship between metabolic syndrome and the concentration of circulating fetuin-A were identified using a systematic search in the electronic databases of Embase, PubMed, Web of Science, and Cochrane Library before March 2019. A random effects model was used to summarize the effect size of the association in terms of the standardized mean difference (SMD). Fourteen eligible studies compared fetuin-A concentrations between 4,551 metabolic syndrome patients and 8,805 controls. The circulating fetuin-A concentration was significantly higher in the metabolic syndrome patients than in the controls (SMD = 0.65, 95% confidence interval (CI): 0.48 to 0.83, Z = 7.18, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0229776