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Effects of maternal hepatitis B surface antigen positive status on the pregnancy outcomes: A retrospective study in Xiamen, China, 2011-2018

Hepatitis B virus infection is a major social and economic burden in developing countries, especially in China. We aimed to evaluate the effects of hepatitis B surface antigen (HBsAg) positive status on the pregnancy outcomes in the Chinese population. This retrospective cohort study was performed u...

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Published in:PloS one 2020-03, Vol.15 (3), p.e0229732-e0229732
Main Authors: Zhao, Yan, Chen, Yin-Ling, Song, Hai-Qu, Huang, Pei-Ying, Wang, Li-Ying, Liu, Wei, Huang, Bing-Kun, Lv, Fu-Ping, Huang, Caoxin, Yan, Bing, Li, Xue-Jun
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cited_by cdi_FETCH-LOGICAL-c692t-7b3e29e830b99841469626a6ddf814a3bd286ddc10c755257b1f80e431d894a93
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creator Zhao, Yan
Chen, Yin-Ling
Song, Hai-Qu
Huang, Pei-Ying
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Liu, Wei
Huang, Bing-Kun
Lv, Fu-Ping
Huang, Caoxin
Yan, Bing
Li, Xue-Jun
description Hepatitis B virus infection is a major social and economic burden in developing countries, especially in China. We aimed to evaluate the effects of hepatitis B surface antigen (HBsAg) positive status on the pregnancy outcomes in the Chinese population. This retrospective cohort study was performed using data from the Medical Birth Registry of Xiamen, China, from January 2011 to March 2018. Multivariate logistic regression analysis was used to assess the association between the HBsAg status and pregnancy outcomes. This study included 3,789 HBsAg-positive women and 29, 648 non-exposed women. The HBsAg-positive pregnant women were slightly older in age (29.3±4.3 vs. 28.9±4.4, P< 0.001). Additionally, pregnant women with a positive HBsAg status had higher odds of gestational diabetes mellitus (GDM) (adjusted odds ratio [aOR], 1.13; 95% confidence interval [CI], 1.03-1.23), and cesarean delivery (aOR, 1.12; 95%CI, 1.03-1.21). The risk of infants being large or small-for-gestational age, having low-birth weight, and of macrosomia, preterm birth, and stillbirth did not differ significantly between the HBsAg-positive and-negative women. In Xiamen, China, the slightly higher risk of GDM and cesarean section in women positive for HBsAg should not be neglected. Further studies should be conducted to evaluate the effects of HBsAg positivity on the pregnancy outcomes in different ethnic populations.
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We aimed to evaluate the effects of hepatitis B surface antigen (HBsAg) positive status on the pregnancy outcomes in the Chinese population. This retrospective cohort study was performed using data from the Medical Birth Registry of Xiamen, China, from January 2011 to March 2018. Multivariate logistic regression analysis was used to assess the association between the HBsAg status and pregnancy outcomes. This study included 3,789 HBsAg-positive women and 29, 648 non-exposed women. The HBsAg-positive pregnant women were slightly older in age (29.3±4.3 vs. 28.9±4.4, P&lt; 0.001). Additionally, pregnant women with a positive HBsAg status had higher odds of gestational diabetes mellitus (GDM) (adjusted odds ratio [aOR], 1.13; 95% confidence interval [CI], 1.03-1.23), and cesarean delivery (aOR, 1.12; 95%CI, 1.03-1.21). 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We aimed to evaluate the effects of hepatitis B surface antigen (HBsAg) positive status on the pregnancy outcomes in the Chinese population. This retrospective cohort study was performed using data from the Medical Birth Registry of Xiamen, China, from January 2011 to March 2018. Multivariate logistic regression analysis was used to assess the association between the HBsAg status and pregnancy outcomes. This study included 3,789 HBsAg-positive women and 29, 648 non-exposed women. The HBsAg-positive pregnant women were slightly older in age (29.3±4.3 vs. 28.9±4.4, P&lt; 0.001). Additionally, pregnant women with a positive HBsAg status had higher odds of gestational diabetes mellitus (GDM) (adjusted odds ratio [aOR], 1.13; 95% confidence interval [CI], 1.03-1.23), and cesarean delivery (aOR, 1.12; 95%CI, 1.03-1.21). The risk of infants being large or small-for-gestational age, having low-birth weight, and of macrosomia, preterm birth, and stillbirth did not differ significantly between the HBsAg-positive and-negative women. In Xiamen, China, the slightly higher risk of GDM and cesarean section in women positive for HBsAg should not be neglected. Further studies should be conducted to evaluate the effects of HBsAg positivity on the pregnancy outcomes in different ethnic populations.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32155166</pmid><doi>10.1371/journal.pone.0229732</doi><tpages>e0229732</tpages><orcidid>https://orcid.org/0000-0001-7966-2100</orcidid><oa>free_for_read</oa></addata></record>
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source Open Access: PubMed Central; Publicly Available Content Database
subjects Age
Analysis
Antibiotics
Antigens
Biology and life sciences
Birth weight
Blood pressure
Body mass index
Cesarean section
Childbirth & labor
Compulsory education
Confidence intervals
Developing countries
Diabetes
Diabetes mellitus
Endocrinology
Evaluation
Gestational age
Gestational diabetes
Health aspects
Hepatitis
Hepatitis B
Hepatitis B surface antigen
Hospitals
Hypertension
Infants
Infection
LDCs
Low birth weight
Medical schools
Medicine and Health Sciences
Pregnancy
Pregnant women
Premature birth
Regression analysis
Small for gestational age
Statistical analysis
Stillbirth
Studies
Variables
Virus diseases
Viruses
Women
Womens health
title Effects of maternal hepatitis B surface antigen positive status on the pregnancy outcomes: A retrospective study in Xiamen, China, 2011-2018
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