HPV genotypic spectrum in Jilin province, China, where non-vaccine-covered HPV53 and 51 are prevalent, exhibits a bimodal age-specific pattern

• Published in: PloS one 2020-03, Vol.15 (3), p.e0230640-e0230640
• Main Authors: Hao, Sijia, Wang, Chunyan, Liu, Siwen, He, Jiaxue, Jiang, Yanfang
• Format: Article
• Language: English
• Subjects: Age; Analysis; Biology and life sciences; Cancer; Cancer research; Cancer screening; Cervical cancer; Cervix; Condyloma acuminatum; Deoxyribonucleic acid; Disease; Disease transmission; Diseases; DNA; Education; Exhibitions; Females; Genital warts; Genotypes; Genotyping; Health risks; Human papilloma viruses; Human papillomavirus; Infection; Infections; Laboratories; Lesions; Medicine and Health Sciences; Men; Morbidity; Papillomavirus; Papillomavirus infections; Prevalence studies (Epidemiology); Screening; Sexually transmitted diseases; Statistical analysis; STD; Vaccination; Vaccines; Warts; Women; Womens health
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0230640

Human papillomavirus (HPV), the most common sexually transmitted disease, is involved in a series of other diseases. The persistent infection of high-risk HPVs (HR-HPVs) is considered to be the causative agent of cervical cancer, and it is related to noncervical cancers. The present study aims to estimate the HPV prevalence and genotype distribution in Jilin province, China, to guide HPV-related cervical cancer screening and HPV vaccination. From October 2017 to September 2019, 21,282 samples (634 male and 20,648 female) were collected for HPV infection detection using an HPV genotyping panel. The age-related HPV prevalence and morbidity of HPV-based disease and HPV prevalence associated with specific diseases were analyzed. A total of 7095 (34.4%) positive for HPV infection of 20648 women, and 164 (25.8%) positive of 634 men. The HPV prevalence among women exhibited a bimodal pattern, with a peak in young group and a second peak in old group, with increased severity of cervical lesions. HPV16 (7.8%), HPV52 (5.8%), HPV58 (5.0%), HPV53 (3.4%), and HPV51 (3.0%) were the most prevalent genotypes among women, and HPV6 (6.0%), HPV11 (5.7%), HPV16 (3.6%), HPV18 (2.7%), and HPV51 (3.0%) were prevalent among men. Non-vaccine-covered HPV53 and 51 were found in 6.3% of HPV infection and 8.9% of cervical cancer in Jilin province. Furthermore, 45.5% of females and 28.6% of males with genital warts were infected with HR-HPV genotypes. The HPV genotypic spectrum in Jilin province, where non-vaccine-covered HPV53 and 51 were prevalent, exhibited an age- and cervical lesion-specific pattern, which provides guidance for HPV vaccination and cervical cancer screening. HPV infection in men and benign hyper-proliferative lesions should not be neglected.