Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells

Previously, quercetin has been reported to be a senolytic, a drug that selectively removes senescent cells, in HUVECs. However, we found neither quercetin nor Q3G was effective as a senolytic for adult human endothelial cells.

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Bibliographic Details
Published in:PloS one 2018-01, Vol.13 (1), p.e0190374-e0190374
Main Authors: Hwang, HyunTae V, Tran, Darlene Thuy, Rebuffatti, Michelle Nicole, Li, Chin-Shang, Knowlton, Anne A
Format: Article
Language:English
Subjects:
Adult
Aging
Apoptosis
Biology and Life Sciences
Cardiology
Cell death
Cell Proliferation - drug effects
Cellular Senescence - drug effects
Coronary artery
Cytotoxicity
Endothelial cells
Endothelium
Endothelium, Vascular - cytology
Endothelium, Vascular - drug effects
Female
Females
Galactosidase
Galactosides
Geriatrics
Gerontology
Glycosides
Health aspects
Human Umbilical Vein Endothelial Cells
Humans
Internal medicine
Medical research
Medicine
Medicine and Health Sciences
Microvasculature
Morphology
People and Places
Physiological aspects
Quercetin
Quercetin - analogs & derivatives
Quercetin - pharmacology
Research and Analysis Methods
Senescence
Umbilical vein
β-Galactosidase
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Description
Summary:Previously, quercetin has been reported to be a senolytic, a drug that selectively removes senescent cells, in HUVECs. However, we found neither quercetin nor Q3G was effective as a senolytic for adult human endothelial cells.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0190374