Advanced case of PKDL due to delayed treatment: A rare case report

Post-kala-azar dermal leishmaniasis (PKDL) is clinical outcome of visceral leishmaniasis (VL) and is thought to be the potential reservoir of parasite. Miltefosine (MF) is the only oral drug existing for treatment of post-kala-azar dermal leishmaniasis (PKDL). Increased miltefosine tolerance in clin...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2020-03, Vol.14 (3), p.e0008052-e0008052
Main Authors: Topno, Roshan Kamal, Rabi Das, Vidya Nand, Kumar, Maneesh, Madhukar, Major, Pandey, Krishna, Verma, Neena, Agrawal, Kanhaiya, Lal, Chandra Shekhar, Siddiqui, Niyamat Ali, Bimal, Sanjiva, Das, Pradeep
Format: Article
Language:English
Subjects:
Antiprotozoal Agents - therapeutic use
Authorship
Biology and life sciences
Blood
Case reports
Case studies
Clinical isolates
Clinical medicine
Diagnosis
Drug dosages
Drug therapy
Hepatitis
Humans
India
Leishmania donovani - isolation & purification
Leishmaniasis
Leishmaniasis, Cutaneous - diagnosis
Leishmaniasis, Cutaneous - drug therapy
Leishmaniasis, Cutaneous - etiology
Leishmaniasis, Cutaneous - parasitology
Leishmaniasis, Visceral - complications
Leishmaniasis, Visceral - diagnosis
Leishmaniasis, Visceral - drug therapy
Leishmaniasis, Visceral - parasitology
Lymphocytes
Male
Medicine
Medicine and Health Sciences
Middle Aged
Miltefosine
Oral administration
Parasites
Parasitic diseases
Pathogenesis
Phosphorylcholine - analogs & derivatives
Phosphorylcholine - therapeutic use
Skin
Skin - diagnostic imaging
Skin - pathology
Symposium
Tolerance
Tropical diseases
Vector-borne diseases
Visceral leishmaniasis
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Description
Summary:Post-kala-azar dermal leishmaniasis (PKDL) is clinical outcome of visceral leishmaniasis (VL) and is thought to be the potential reservoir of parasite. Miltefosine (MF) is the only oral drug existing for treatment of post-kala-azar dermal leishmaniasis (PKDL). Increased miltefosine tolerance in clinical isolates of Leishmania donovani has been reported and is one of the major concerns in the treatment of PKDL. Here, we report a highly ulcerated PKDL case that was successfully cured after miltefosine treatment.
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0008052