Diagnostic utility of the neutrophil-platelet ratio as a novel marker of activity in patients with Ulcerative Colitis

Ulcerative colitis (UC) is a chronic disease characterized by periods of activity and remission. The platelet, one of the main activators of neutrophils, contains Interleukin 8 (IL-8), a potent neutrophil chemo-attractant and P-selectin that induces excretion of superoxide in the neutrophils, formin...

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Bibliographic Details
Published in:PloS one 2020-04, Vol.15 (4), p.e0231988-e0231988
Main Authors: Yamamoto-Furusho, Jesús K, Mendieta-Escalante, Erick A
Format: Article
Language:English
Subjects:
Albumins
Biology and Life Sciences
Biomarkers
Blood platelets
Blood tests
C-reactive protein
Chronic illnesses
Colon
Correlation analysis
Diagnostic systems
Endoscopy
Erythrocyte sedimentation rate
Erythrocytes
Feces
Gastroenterology
Histopathology
Inflammatory bowel disease
Interleukin 8
Laboratories
Leukocytes (neutrophilic)
Medical diagnosis
Medicine and Health Sciences
Neutrophils
Nutrition
P-selectin
Platelets
Remission
Superoxide
Ulcerative colitis
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Summary:Ulcerative colitis (UC) is a chronic disease characterized by periods of activity and remission. The platelet, one of the main activators of neutrophils, contains Interleukin 8 (IL-8), a potent neutrophil chemo-attractant and P-selectin that induces excretion of superoxide in the neutrophils, forming platelet-neutrophil aggregates that are increased in individuals with active UC, hence an index of both cells could produce a monitoring tool. No previous studies have evaluated this ratio in UC. To evaluate the clinical utility of the Neutrophil-Platelet (NeuPla) ratio in patients with UC. A total of 158 patients with a diagnosis of UC. This index was based on the ratio between platelets and the neutrophil differential in blood count. The activity was classified using Mayo endoscopic sub-score, histological (Riley score) and for clinical was used the Truelove-Witts, Montreal, Mayo and Yamamoto-Furusho scores. The correlation of the NeuPla ratio with activity scales were significant (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0231988