Clinical characteristics and long-term evolution of lamellar macular hole in high myopia

To evaluate the clinical characteristics and evolution of lamellar macular hole (LMH) in high myopia and the parameters associated with structural worsening, defined as the development of foveal detachment or full-thickness macular hole. Patients with high myopia and LMH were retrospectively recruit...

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Bibliographic Details
Published in:PloS one 2020-05, Vol.15 (5), p.e0232852-e0232852
Main Authors: Hsia, Yun, Ho, Tzyy-Chang, Yang, Chang-Hao, Hsieh, Yi-Ting, Lai, Tso-Ting, Yang, Chung-May
Format: Article
Language:English
Subjects:
Atrophy
Biology and Life Sciences
Chi-square test
Development and progression
Diagnosis
Evolution
Hospitals
Macula lutea
Medical examination
Medicine
Medicine and Health Sciences
Myopia
Optical Coherence Tomography
Parameter identification
Physical Sciences
Regression analysis
Research and Analysis Methods
Retinoschisis
Social Sciences
Statistical analysis
Surgery
Thickness
Tissues
Tomography
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Summary:To evaluate the clinical characteristics and evolution of lamellar macular hole (LMH) in high myopia and the parameters associated with structural worsening, defined as the development of foveal detachment or full-thickness macular hole. Patients with high myopia and LMH were retrospectively recruited. The clinical characteristics and various parameters of optical coherence tomography were identified at baseline and during follow-up visits. Cox regression analysis was used to evaluate the hazard ratios for foveal detachment and full-thickness macular hole. Among 112 eyes (98 patients), 64.3% were female; the mean axial length of all eyes was 29.6 ± 1.9 mm. The 'LMH without retinoschisis' group accounted for 39.3% of the eyes. Forty-two percent developed structural worsening within a median follow-up of 67 months. Multivariable regression on all cases showed elevated tissue inside the LMH (P = 0.003) protected against structural worsening while V-shaped LMH (P = 0.006) predicted it. In the "LMH with retinoschisis group", ellipsoid zone disruption (P = 0.035), and V-shaped LMH (P = 0.014) predicted structural worsening, while elevated tissue inside the LMH (P = 0.028) protected against it. In the "LMH without retinoschisis group", no associated factor was identified. LMHs in high myopia are unstable, especially those with V-shaped LMH. Elevated tissue inside LMHs have a protective effect against further structural worsening.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0232852