Late pregnancy screening for preeclampsia with a urinary point-of-care test for misfolded proteins

The aim was to describe and assess a new late pregnancy point-of-care urinary preeclampsia screening test. Urine samples were collected from a consecutive series of 1,532 pregnant women hospitalized at 20-41 weeks gestation in a Chinese single obstetric unit. A simple disposable Congo red based devi...

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Bibliographic Details
Published in:PloS one 2020-05, Vol.15 (5), p.e0233214-e0233214
Main Authors: Li, Xing-Min, Liu, Xue-Min, Xu, Jun, Du, Juan, Cuckle, Howard
Format: Article
Language:English
Subjects:
Age
Biology and Life Sciences
Biomarkers
Blood pressure
Cellulose
Diagnosis
Gestation
Gestational diabetes
Gynecology
Medicine and Health Sciences
Methods
Obstetrical diagnosis
Obstetrics
Pre-eclampsia
Preeclampsia
Pregnancy
Pregnant women
Protein folding
Proteins
Risk factors
Screening
Statistical analysis
Urinalysis
Urine
Women
Womens health
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Summary:The aim was to describe and assess a new late pregnancy point-of-care urinary preeclampsia screening test. Urine samples were collected from a consecutive series of 1,532 pregnant women hospitalized at 20-41 weeks gestation in a Chinese single obstetric unit. A simple disposable Congo red based device was newly developed and employed to prospectively test misfolded proteins in pregnant women's urine. A total of 140 preeclampsia cases were clinically diagnosed, 101 severe and 87 pre-term. Detection and false positive rates were similar in the training and validation subsets with combined 74% and 3.0%. The detection rate was 83% in severe, 86% in pre-term, 49% and 50% in mild and term cases (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0233214