Cerebrospinal fluid levels of neuron-specific enolase predict the severity of brain damage in newborns with neonatal hypoxic-ischemic encephalopathy treated with hypothermia

Objectives To investigate whether cerebrospinal fluid levels of neuron-specific enolase (CSF-NSE) during the first 72 hours correlate with other tools used to assess ongoing brain damage, including clinical grading of hypoxic-ischemic encephalopathy (HIE), abnormal patterns in amplitude integrated e...

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Bibliographic Details
Published in:PloS one 2020-06, Vol.15 (6), p.e0234082-e0234082
Main Authors: León-Lozano, Marisol-Zulema, Arnaez, Juan, Valls, Ana, Arca, Gemma, Agut, Thais, Alarcón, Ana, Garcia-Alix, Alfredo, Gressens, Pierre
Format: Article
Language:English
Subjects:
Abnormalities
Biology and Life Sciences
Biomarkers
Brain
Brain damage
Brain injury
Brain-damaged children
Care and treatment
Cerebrospinal fluid
Damage assessment
Diagnostic imaging
EEG
Electroencephalography
Encephalopathy
Health aspects
Hypothermia
Hypoxia
Infants
Ischemia
Levels
Magnetic resonance
Magnetic resonance imaging
Measurement
Medical imaging
Medicine and Health Sciences
Neonatal diseases
Neonates
Nervous system
Neurodevelopment
Neuroimaging
Neurons
Neurophysiology
Newborn babies
Newborn infants
Patient outcomes
People and Places
Phosphopyruvate hydratase
Research and Analysis Methods
Risk factors
Seizures
Seizures (Medicine)
Studies
Traumatic brain injury
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Summary:Objectives To investigate whether cerebrospinal fluid levels of neuron-specific enolase (CSF-NSE) during the first 72 hours correlate with other tools used to assess ongoing brain damage, including clinical grading of hypoxic-ischemic encephalopathy (HIE), abnormal patterns in amplitude integrated electroencephalography (aEEG), and magnetic resonance imaging (MRI), as well as with the neurodevelopmental outcomes at two years of age. Material and methods Prospective observational study performed in two hospitals between 2009 and 2011. Forty-three infants diagnosed with HIE within 6 hours of life were included. HIE was severe in 20 infants, moderate in 12, and mild in 11. Infants with moderate-to-severe HIE received whole-body cooling. Both the HIE cohort and a control group of 59 infants with suspected infection underwent measurement of CSF-NSE concentrations at between 12 and 72 hours after birth. aEEG monitoring was started at admission and brain MRI was performed within the first 2 weeks. Neurodevelopment was assessed at 24 months. Results The HIE group showed higher levels of CSF-NSE than the control group: median 70 ng/ml (29; 205) vs 10.6 ng/ml (7.7; 12.9); p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0234082