Loss of association between HbA1c and vascular disease in older adults with type 1 diabetes

• Published in: PloS one 2020-06, Vol.15 (6), p.e0234319-e0234319
• Main Authors: Ji, HaEun, Godsland, Ian, Oliver, Nick S, Hill, Neil E
• Format: Article
• Language: English
• Subjects: Adults; Age; Age groups; Biology and life sciences; Blood glucose; Blood pressure; Cholesterol; Complications; Complications and side effects; Continuity (mathematics); Diabetes; Diabetes mellitus; Diabetes mellitus (insulin dependent); Disease; Elderly; Endocrinology; Glucose; Glycosylated hemoglobin; Health aspects; Health risk assessment; Health risks; Hemoglobin; High density lipoprotein; Hypertension; Hypotheses; Independent variables; Lipids; Medical records; Medicine and health sciences; Metabolism; Microvasculature; Older people; Patients; People and Places; Regression analysis; Risk analysis; Risk factors; Statistics; Type 1 diabetes; Variables; Vascular diseases
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0234319

Robust evidence supports intensive glucose control in those with recently diagnosed type 1 diabetes to reduce the risk of developing micro- and macrovascular complications. Data to support longitudinal glycaemic targets is lacking. We aimed to explore if longer duration of diabetes and greater age might reduce the impact of glycaemia on the risk of vascular complications. Data for adults age 20 years or more, was extracted from a clinical database of people with type 1 diabetes cared for at a London teaching hospital. The presence or absence of micro- and macro-vascular complications was recorded. Multivariable logistic regression analysis was performed using HbA1c as independent variable, diabetes duration and age as continuous variable and obesity, hypertension, hypercholesterolaemia, low HDL cholesterol and hypertriglyceridaemia as categorical variables. Data from 495 patients was used. HbA1c above 60 mmol/mol (7.6%) was associated with increased microvascular complications in patients aged 20-44 years, independent of age and duration of diabetes. In older people with T1DM duration of diabetes was the major risk factor. Our study suggests that increased age and greater duration of diabetes reduce the impact of glycaemia on the risk of vascular complications. Intensive blood glucose management in patients aged [greater than or equal to]45 years may have limited benefits in terms of reducing the risk of complications although this does not dismiss the benefits of good glycaemic control in older people with T1DM.