Prevalence and risk factors for Trichomonas vaginalis infection among adults in the U.S., 2013-2014

• Published in: PloS one 2020-06, Vol.15 (6), p.e0234704-e0234704
• Main Authors: Tompkins, Erin L, Beltran, Thomas A, Gelner, Elizabeth J, Farmer, Aaron R
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Adults; Biology and Life Sciences; Biomarkers; Clinical medicine; Confidence intervals; Cotinine; Cotinine - blood; Data collection; Demographics; Disease; Education; Estimates; Ethnicity; Exposure; Female; Health risks; Hispanic people; HIV; Human immunodeficiency virus; Humans; Infections; Institutionalization; Laboratories; Male; Medicine and Health Sciences; Men; Middle Aged; Morbidity; Nicotine; Nutrition; Nutrition Surveys; Odds Ratio; Parasitic diseases; People and Places; Population; Populations; Poverty; Prevalence; Risk analysis; Risk Factors; Screening; Sexual Behavior; Sexually transmitted diseases; Smoking; Social Sciences; Socioeconomics; Statistics; STD; Tobacco; Trichomonas Infections - diagnosis; Trichomonas Infections - epidemiology; Trichomonas Infections - ethnology; Trichomonas Infections - parasitology; Trichomonas vaginalis; Trichomonas vaginalis - isolation & purification; Trichomoniasis; United States - epidemiology; Urine; Vagina; Women; Womens health; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0234704

Trichomonas vaginalis (TV) infection is common, curable, and associated with significant reproductive morbidity and risk for HIV infection. This analysis updates estimates of the prevalence of asymptomatic TV infection, and its associated risk factors, in the non-institutionalized U.S. population. We analyzed data from 4057 individuals who participated in the National Health and Nutrition Examination Survey (NHANES) 2013-2014 data collection cycle. Participant interviews ascertained demographic characteristics, self-reported tobacco use, and sexual history. Self-collected urine specimens from participants aged 18 to 59 years were tested for TV infection using the Gen-Probe Aptima TV assay. Cotinine was assayed from serum to provide a biomarker of recent tobacco exposure. Weighted percentages are provided to account for unequal selection probabilities among participants and adjustments for non-response. Our sample included 1942 men (49.2%, 95% Confidence Interval [CI] 48.0-50.5) and 2115 women (50.8%, 95%CI 49.5-52.0). The infection prevalence among men was 0.5% (n = 16; 95%CI 0.2-1.0) and 1.8% (n = 55; 95%CI 1.1-3.1) in women. After controlling for participant characteristics associated with TV infection, females had a 5.2-fold increased odds of being infected compared to men (adjusted odds ratio (aOR) 5.2, 95% CI 2.4-11.4). Non-Hispanic blacks were more likely to be infected compared to non-Hispanic whites (aOR 11.2, 95% CI 4.6-27.2). Individuals below the federal poverty level were more likely to be infected compared to those earning >3 times the federal poverty level (aOR 6.7, 95% CI 1.7-26.6), and active smokers were more likely to be infected compared to participants with no nicotine exposure (aOR 8.7, 95% CI 4.1-18.2). Trichomonas vaginalis infection continues to be relatively common, especially in women, smokers, non-Hispanic blacks, and in groups of lower socioeconomic status. Identifying the demographic characteristics of populations in the United States disproportionately affected by TV could impact screening and treatment of this infection in clinical practice. Further research on whether screening and treating for asymptomatic TV infection in high-risk populations improves risk for reproductive morbidity and HIV infection is warranted.