Correction: S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson’s disease

• Published in: PloS one 2020-06, Vol.15 (6), p.e0235296-e0235296
• Main Authors: Wu, Weiwei, Sung, Chun Chau, Yu, Peichun, Li, Jiahua, Chung, Kenny K. K
• Format: Article
• Language: English
• Subjects: Animal models; Animals; Brain; Casein; Casein kinase II; Format; G protein-coupled receptor kinase; G protein-coupled receptor kinase 6; Glyceraldehyde-3-phosphate dehydrogenase; In vivo methods and tests; Kinases; Medical imaging; Movement disorders; Neurodegenerative diseases; Parkinson's disease; Phosphorylation; Proteins; Rodents; Synuclein; Thumbnail icons; Transgenic animals; Transgenic mice; Variance analysis
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0235296

The samples were also subject to Western blot analysis of GRK6, CK2α, GAPDH, pSer129 α-syn and α-syn. (→: GRK6 band) (B) Quantification of hemizygous A53T α-syn transgenic mouse brain samples for in vivo CK2α S-nitrosylation as in (A) (* p < 0.05, ** p < 0.01; # of animals = 3 for each time point; one-way ANOVA with Bonferroni post-hoc test). (F) Quantification of hemizygous A53T α-syn transgenic mouse brain samples for protein levels of α-syn as in (A) (# of animals = 3 for each time point). https://doi.org/10.1371/journal.pone.0235296.g001 thumbnail Download: * PPT PowerPoint slide * PNG larger image * TIFF original image Fig 4. The samples were also subject to Western blot analysis of CK2α, GAPDH, pSer129 α-syn and α-syn. (→: GRK6 band) (B) Quantification of WT and hemizygous A53T α-syn transgenic mouse brain samples for in vivo CK2α S-nitrosylation as in (A) (* p < 0.05; no. of animals = 3 in each group; two-way ANOVA with Bonferroni post-hoc test).