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Anthropometric indices and cut-off points in the diagnosis of metabolic disorders
Identifying metabolic disorders at the earliest phase of their development allows for an early intervention and the prevention of serious consequences of diseases. However, it is difficult to determine which of the anthropometric indices of obesity is the best tool for diagnosing metabolic disorders...
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Published in: | PloS one 2020-06, Vol.15 (6), p.e0235121-e0235121 |
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description | Identifying metabolic disorders at the earliest phase of their development allows for an early intervention and the prevention of serious consequences of diseases. However, it is difficult to determine which of the anthropometric indices of obesity is the best tool for diagnosing metabolic disorders. The aims of this study were to evaluate the usefulness of selected anthropometric indices and to determine optimal cut-off points for the identification of single metabolic disorders that are components of metabolic syndrome (MetS). Cross-sectional study. We analyzed the data of 12,328 participants aged 55.7±5.4 years. All participants were of European descent. The following indices had the highest discriminatory power for the identification of at least one MetS component: CUN-BAE, BMI, and WC in men (AUC = 0.734, 0.728, and 0.728, respectively) and WHtR, CUN-BAE, and WC in women (AUC = 0.715, 0.714, and 0.712, respectively) (p |
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However, it is difficult to determine which of the anthropometric indices of obesity is the best tool for diagnosing metabolic disorders. The aims of this study were to evaluate the usefulness of selected anthropometric indices and to determine optimal cut-off points for the identification of single metabolic disorders that are components of metabolic syndrome (MetS). Cross-sectional study. We analyzed the data of 12,328 participants aged 55.7±5.4 years. All participants were of European descent. The following indices had the highest discriminatory power for the identification of at least one MetS component: CUN-BAE, BMI, and WC in men (AUC = 0.734, 0.728, and 0.728, respectively) and WHtR, CUN-BAE, and WC in women (AUC = 0.715, 0.714, and 0.712, respectively) (p<0.001 for all). The other indices were similarly useful, except for the ABSI. For the BMI, the optimal cut-off point for the identification of metabolic abnormalities was 27.2 kg/m.sup.2 for both sexes. For the WC, the optimal cut-off point was of 94 cm for men and 87 cm for women. Prospective studies are needed to identify those indices in which changes in value predict the occurrence of metabolic disorders best.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0235121</identifier><identifier>PMID: 32569336</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Abnormalities ; Adipose tissue ; Anthropometry ; Biology and Life Sciences ; Blood levels ; Blood pressure ; Body fat ; Body mass ; Body mass index ; Body measurements ; Body size ; Cardiovascular disease ; Cholesterol ; Diabetes ; Diagnosis ; Enzymes ; Health sciences ; Hypertension ; Identification ; Insulin resistance ; Kinases ; Liver diseases ; Low density lipoprotein ; Medical diagnosis ; Medical schools ; Medicine and Health Sciences ; Metabolic diseases ; Metabolic disorders ; Metabolic syndrome ; Metabolites ; Obesity ; Overweight ; Risk factors ; Roundness ; Shape ; Studies ; Triglycerides</subject><ispartof>PloS one, 2020-06, Vol.15 (6), p.e0235121-e0235121</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Głuszek et al. 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However, it is difficult to determine which of the anthropometric indices of obesity is the best tool for diagnosing metabolic disorders. The aims of this study were to evaluate the usefulness of selected anthropometric indices and to determine optimal cut-off points for the identification of single metabolic disorders that are components of metabolic syndrome (MetS). Cross-sectional study. We analyzed the data of 12,328 participants aged 55.7±5.4 years. All participants were of European descent. The following indices had the highest discriminatory power for the identification of at least one MetS component: CUN-BAE, BMI, and WC in men (AUC = 0.734, 0.728, and 0.728, respectively) and WHtR, CUN-BAE, and WC in women (AUC = 0.715, 0.714, and 0.712, respectively) (p<0.001 for all). The other indices were similarly useful, except for the ABSI. For the BMI, the optimal cut-off point for the identification of metabolic abnormalities was 27.2 kg/m.sup.2 for both sexes. 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disorders</atitle><jtitle>PloS one</jtitle><date>2020-06-22</date><risdate>2020</risdate><volume>15</volume><issue>6</issue><spage>e0235121</spage><epage>e0235121</epage><pages>e0235121-e0235121</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Identifying metabolic disorders at the earliest phase of their development allows for an early intervention and the prevention of serious consequences of diseases. 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subjects | Abnormalities Adipose tissue Anthropometry Biology and Life Sciences Blood levels Blood pressure Body fat Body mass Body mass index Body measurements Body size Cardiovascular disease Cholesterol Diabetes Diagnosis Enzymes Health sciences Hypertension Identification Insulin resistance Kinases Liver diseases Low density lipoprotein Medical diagnosis Medical schools Medicine and Health Sciences Metabolic diseases Metabolic disorders Metabolic syndrome Metabolites Obesity Overweight Risk factors Roundness Shape Studies Triglycerides |
title | Anthropometric indices and cut-off points in the diagnosis of metabolic disorders |
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