Effects of sustained inflation pressure during neonatal cardiopulmonary resuscitation of asphyxiated piglets

• Published in: PloS one 2020-06, Vol.15 (6), p.e0228693-e0228693
• Main Authors: Shim, Gyu-Hong, Kim, Seung Yeun, Cheung, Po-Yin, Lee, Tze-Fun, O'Reilly, Megan, Schmölzer, Georg M, Nair, Jayasree
• Format: Article
• Language: English
• Subjects: Asphyxia; Biology and Life Sciences; Blood flow; Blood pressure; Carbon dioxide; Cardiopulmonary resuscitation; Catheters; Cerebral cortex; Compression; CPR; Cytokines; Dentistry; Experiments; Gas flow; Health aspects; Heart rate; Hemodynamics; Hemoglobin; Hospitals; Hypoxia; IL-1β; Inflammation; Inflation; Interleukin; Interleukins; Medical prognosis; Medical research; Medicine; Medicine and Health Sciences; Methods; Morphine; Neonates; Newborn babies; Ostomy; Oxygen saturation; Oxygenation; Parameters; Pediatrics; Physical Sciences; Pips; Pressure effects; Recovery; Resuscitation; Testing; Tumor necrosis factor-α; Tumors; Veins & arteries; Ventilators
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0228693

Sustained inflation (SI) during chest compression (CC = CC+SI) has been recently shown as an alternative method during cardiopulmonary resuscitation in neonates. However, the optimal peak inflation pressure (PIP) of SI during CC+SI to improve ROSC and hemodynamic recovery is unknown. To examine if different PIPs of SI during CC+SI will improve ROSC and hemodynamic recovery in severely asphyxiated piglets. Twenty-nine newborn piglets (1-3 days old) were anesthetized, intubated, instrumented and exposed to 30-min normocapnic hypoxia followed by asphyxia. Piglets were randomized into four groups: CC+SI with a PIP of 10 cmH.sub.2 O (CC+SI_PIP_10, n = 8), a PIP of 20 cmH.sub.2 O (CC+SI_PIP_20, n = 8), a PIP of 30 cmH.sub.2 O (CC+SI_PIP_30, n = 8), and a sham-operated control group (n = 5). Heart rate, arterial blood pressure, carotid blood flow, cerebral oxygenation, and respiratory parameters were continuously recorded throughout the experiment. Baseline parameters were similar between all groups. There was no difference in asphyxiation (duration and degree) between intervention groups. PIP correlated positively with tidal volume (V.sub.T) and inversely with exhaled CO.sub.2 during cardiopulmonary resuscitation. Time to ROSC and rate of ROSC were similar between piglets resuscitated with CC+SI_PIP_10, CC+SI_PIP_20, and CC+SI_PIP_30 cmH.sub.2 O: median (IQR) 75 (63-193) sec, 94 (78-210) sec, and 85 (70-90) sec; 5/8 (63%), 7/8 (88%), and 3/8 (38%) (p = 0.56 and p = 0.12, respectively). All piglets that achieved ROSC survived to four hours post-resuscitation. Piglets resuscitated with CC+SI_PIP_30 cmH.sub.2 O exhibited increased concentrations of pro-inflammatory cytokines interleukin-1[beta] and tumour necrosis factor-[alpha] in the frontoparietal cerebral cortex (both p