Effect of bovine leukemia virus (BLV) infection on bovine mammary epithelial cells RNA-seq transcriptome profile

Bovine leukemia virus (BLV) is a [delta]-retrovirus responsible for Enzootic Bovine Leukosis (EBL), a lymphoproliferative disease that affects cattle. The virus causes immune system deregulation, favoring the development of secondary infections. In that context, mastitis incidence is believed to be...

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Bibliographic Details
Published in:PloS one 2020-06, Vol.15 (6), p.e0234939-e0234939
Main Authors: Cuesta, Lucia Martinez, Liron, Juan Pedro, Nieto Farias, María Victoria, Dolcini, Guillermina Laura, Ceriani, Maria Carolina
Format: Article
Language:English
Subjects:
Analysis
Biology and Life Sciences
Bovine leukosis
Cattle
Cell lines
Collagen
Deregulation
Diagnosis
Epithelial cells
Gene expression
Genes
Genetic aspects
Genomes
Health aspects
Immune response
Immune system
Immunoproliferative diseases
Infections
Interferon
Leukemia
Leukosis
Lymphocytes
Lymphocytes T
Mammary gland
Mammary glands
Mastitis
Medicine and Health Sciences
Methods
Pathogens
Research and Analysis Methods
Ribonucleic acid
RNA
RNA sequencing
Tumor suppressor genes
Virology
Viruses
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Summary:Bovine leukemia virus (BLV) is a [delta]-retrovirus responsible for Enzootic Bovine Leukosis (EBL), a lymphoproliferative disease that affects cattle. The virus causes immune system deregulation, favoring the development of secondary infections. In that context, mastitis incidence is believed to be increased in BLV infected cattle. The aim of this study was to analyze the transcriptome profile of a BLV infected mammary epithelial cell line (MAC-T). Our results show that BLV infected MAC-T cells have an altered expression of IFN I signal pathway and genes involved in defense response to virus, as well as a collagen catabolic process and some protooncogenes and tumor suppressor genes. Our results provide evidence to better understand the effect of BLV on bovine mammary epithelial cell's immune response.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0234939