Endobronchial ultrasound-guided transbronchial needle aspiration versus mediastinoscopy for mediastinal staging of lung cancer: A systematic review of economic evaluation studies

Introduction The emergence of endobronchial ultrasound (EBUS) changed the approach to staging lung cancer. As a new method being incorporated, the use of EBUS may lead to a shift in clinical and costs outcomes. Objective The aim of this systematic review is to gather information to better understand...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2020-06, Vol.15 (6), p.e0235479-e0235479
Main Authors: Steinhauser Motta, João Pedro, Steffen, Ricardo E, Samary Lobato, Caroliny, Souza Mendonça, Vanessa, Lapa e Silva, José Roberto, Lin, Jules, Groth, Shawn
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Clinical trials
Comparative analysis
Cost analysis
Data bases
Diagnosis
Documents
Economic analysis
Economic impact
Evaluation
Impact analysis
Keywords
Lung cancer
Lung diseases
Mediastinoscopy
Medicine and Health Sciences
Patients
Quality assessment
Quality control
Research and Analysis Methods
Reviews
Social Sciences
Systematic review
Ultrasonic imaging
Ultrasound
Ultrasound imaging
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction The emergence of endobronchial ultrasound (EBUS) changed the approach to staging lung cancer. As a new method being incorporated, the use of EBUS may lead to a shift in clinical and costs outcomes. Objective The aim of this systematic review is to gather information to better understand the economic impact of implementing EBUS. Methods This review is reported according to the PRISMA statement and registered on PROSPERO (CRD42019107901). Search keywords were elaborated considering descriptors of terms related to the disease (lung cancer / mediastinal staging of lung cancer) and the technologies of interest (EBUS and mediastinoscopy) combined with a specific economic filter. The literature search was performed in MEDLINE, EMBASE, LILACS, Cochrane Library of Trials, Web of Science, Scopus and National Health System Economic Evaluation Database (NHS EED) of the Center for Reviews and Dissemination (CRD). Screening, selection of articles, data extraction and quality assessment were carried out by two reviewers. Results Seven hundred and seventy publications were identified through the database searches. Eight articles were included in this review. All publications are full economic evaluation studies, one cost-effectiveness, three cost-utility, and four cost-minimization analyses. The costs of strategies using EBUS-TBNA were lower than the ones using mediastinoscopy in all studies analyzed. Two of the best quality scored studies demonstrate that the mediastinoscopy strategy is dominated by the EBUS-TBNA strategy. Conclusion Information gathered in the eight studies of this systematic review suggest that EBUS is cost-effective compared to mediastinoscopy for mediastinal staging of lung cancer.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0235479