Low venous thromboembolism incidence in high risk medical patients in an Israeli hospital. Can risk assessment be extrapolated to different populations?

• Published in: PloS one 2020-07, Vol.15 (7), p.e0235683-e0235683
• Main Authors: Koren, Ofir, Nasser, Arin, Elias, Mazen, Avraham, Gilat, Freidberg, Nahum, Saliba, Walid, Goldstein, Lee H, Serra, Raffaele
• Format: Article
• Language: English
• Subjects: Anticoagulants; Biology and Life Sciences; Drug dosages; Health services; Hospital patients; Hospitalization; Hospitals; Internal medicine; Medicine; Medicine and Health Sciences; Molecular weight; Mortality; Patients; People and Places; Populations; Prognosis; Prophylaxis; Pulmonary embolisms; Risk assessment; Risk factors; Risk groups; Risk management; Risk reduction; Sample size; Statistics; Thromboembolism; Thrombosis; Veins & arteries; Venous thrombosis
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0235683

Guidelines recommend venous thromboembolism (VTE) prophylaxis in hospitalized medical patients with Padua prediction score (PPS) [greater than or equal to]4 points. This recommendation is based on the high risk of symptomatic VTE observed among these patients in the Italian PPS derivation study, and the fivefold risk reduction with VTE-prophylaxis. This study aims to assess the incidence of VTE in high risk medical patients in a medium sized hospital in Israel. In this retrospective cohort study, data was collected of all medical patients hospitalized between January and June 2014. Patients were classified into low and high risk groups according to their PPS score, and according to whether they received anticoagulant thromboprophylaxis for VTE. Patients were further randomly selected to compare high risk patients that did or did not receive anticoagulant thromboprophylaxis. We further compared VTE incidence in high and low risk patients not treated with thromboprophylaxis. A search was conducted for diagnoses of venous thromboembolism and death during hospitalization and the following 90 days. 568 high risk patients (PPS [greater than or equal to]4 points) were included, 284 treated with prophylactic anticoagulation and 284 not. There were no VTE events in either group. There was no difference in mortality. A total of 642 non anticoagulated patients were randomly selected, 474 low risk and 168 high risk. There were no VTE events in either group. The risk of VTE appears to be very low in our study, suggesting that among medical patients with PPS [greater than or equal to]4, the risk of VTE may differ dramatically between populations.