Comparison of the detection rate of cervical lesion with TruScreen, LBC test and HPV test: A Real-world study based on population screening of cervical cancer in rural areas of China

• Published in: PloS one 2020-07, Vol.15 (7), p.e0233986-e0233986
• Main Authors: Ma, Yu, Di, Jiangli, Bi, Hui, Zhao, Qingping, Qin, Tianhua, Xu, Wen, Liu, Zhaoyang, Yi, Nianhua, Zhao, Jing, Zhou, Deping, Chen, Jiancui, Yang, Qi
• Format: Article
• Language: English
• Subjects: Adult; Alphapapillomavirus; Biology and life sciences; Biopsy; Cancer; Cancer screening; Cancer therapies; Cellular biology; Cervical cancer; Cervix; Children & youth; Childrens health; China - epidemiology; Colposcopy; Diagnosis; Disease control; Disease prevention; Early Detection of Cancer - methods; Early Detection of Cancer - statistics & numerical data; Earth Sciences; Economic development; Female; Geography, Medical; Gynecology; Hospitals; Human papillomavirus; Humans; Management; Maternal & child health; Medical diagnosis; Medical screening; Medicine and Health Sciences; Methods; Middle Aged; Mortality; Papillomavirus Infections - diagnosis; Papillomavirus Infections - epidemiology; Papillomavirus Infections - pathology; People and Places; Population; Population studies; Prevalence; Program Evaluation; Real time operation; Rural areas; Rural health services; Rural Population; Screening; Statistical analysis; Statistical methods; Statistics; Studies; Uterine Cervical Dysplasia - diagnosis; Uterine Cervical Dysplasia - epidemiology; Uterine Cervical Dysplasia - pathology; Uterine Cervical Neoplasms - diagnosis; Uterine Cervical Neoplasms - epidemiology; Uterine Cervical Neoplasms - pathology; Vaginal Smears - methods; Womens health
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0233986

China carries a heavy burden of cervical cancer and has an alarmingly low cervical cancer screening rate. In order to achieve the goal of cervical cancer elimination, there is an urgent need for suitable methods and strategies in China. A total 9972 woman who received cervical cancer screening services of National Cervical Cancer Screening Program in Rural Areas (NCCSPRA) in 8 project counties participated in this study. TruScreen, HPV test and LBC test were performed in all participants. A total of 1945women had one or more than one positive or abnormal screening results of the above three screening tests subsequently received colposcopy. The detection rate of CIN2+ between the three tests were compared. No matter what kind of screening method is used, the CIN2+ detection rate in the eastern regions was much higher than that in the central and western regions. The total detection rate of CIN2+ in HPV group was highest (0.73%), following in LBC group (0.44%) and TS group (0.31%). There was statistically significant difference in the total detection rate of CIN2+ between TS and HPV groups, LBC and HPV groups, respectively. There was no statistical difference in the total detection rate of CIN2+ between TS and LBC screening groups. Moreover, except for the eastern regions, there was no statistical difference in the detection rate of CIN2+ between TS group and the other two groups in central and western regions. If it can meet the requirements of the laboratory and personnel, HPV test seems to be the preferred method for cervical cancer screening in rural areas of China. The characteristics of minimal training requirements, simple operation, real-time results obtained without the collection of cervical cell samples and the help of laboratory equipment and cytologists of TS make it ideal for cervical cancer screening in low-resource regions.