Effect of delayed palliative chemotherapy on survival of patients with recurrent ovarian cancer

For patients with recurrent ovarian cancer, the goals of chemotherapy include palliation of disease-related symptoms with minimum treatment-related side effects. However, there is currently a paucity of data regarding the initiation of palliative chemotherapy. This study aimed to compare the differe...

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Bibliographic Details
Published in:PloS one 2020-07, Vol.15 (7), p.e0236244
Main Authors: Pyeon, Seung Yeon, Han, Gwan Hee, Ki, Kyung Do, Lee, Kwang-Beom, Lee, Jong-Min
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Cancer
Cancer therapies
Chemotherapy
Chi square analysis
Chi-square test
Cost benefit analysis
Gynecology
Hospitals
Medical diagnosis
Medical treatment
Medicine and Health Sciences
Neutropenia
Obstetrics
Ovarian cancer
Ovarian carcinoma
Palliation
Palliative care
Patients
Quality of life
Side effects
Signs and symptoms
Software
Statistical analysis
Statistical tests
Survival
Survival analysis
Toxicity
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Summary:For patients with recurrent ovarian cancer, the goals of chemotherapy include palliation of disease-related symptoms with minimum treatment-related side effects. However, there is currently a paucity of data regarding the initiation of palliative chemotherapy. This study aimed to compare the differences in survival rates and toxicities between patients with recurrent ovarian cancer who started palliative chemotherapy immediately versus those who received delayed chemotherapy. Through a retrospective chart review, patients who received more than three lines of chemotherapy were included. Based on the timing of third-line chemotherapy initiation, the patients were divided into two groups: delayed (DTG) and immediate (ITG) treatment groups. The chi-square test or Fisher’s exact tests, and t-test or Mann-Whitney U test were used for comparing variables, as appropriate. The Kaplan-Meier method was used for survival analysis. P-value of
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0236244