Maternal diabetes mellitus as an independent risk factor for clinically significant retinopathy of prematurity severity in neonates less than 1500g

Retinopathy of prematurity (ROP) is a significant morbidity in preterm babies. Multiple risk factors for severe ROP have been extensively studied, however, only a few studies have included maternal diabetes mellitus (MDM) in their assessment. ROP and diabetic retinopathy are both retinal vascular di...

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Bibliographic Details
Published in:PloS one 2020-08, Vol.15 (8), p.e0236639-e0236639
Main Authors: Opara, Chibuzor Nonye, Akintorin, Mopelola, Byrd, Allison, Cirignani, Natascha, Akintorin, Similolu, Soyemi, Kenneth
Format: Article
Language:English
Subjects:
Babies
Biology and Life Sciences
Birth weight
Blood vessels
Chi square analysis
Chi-square test
Chorioamnionitis
Clinical significance
Complications and side effects
Data collection
Diabetes mellitus
Diabetic retinopathy
Disease
Electronic health records
Epidemics
Ethnicity
Gestational age
Gestational diabetes
Health aspects
Health risks
Hospitals
Hyperglycemia
Industrialized nations
Infants
Low birth weight
Medical personnel
Medical records
Medicine and Health Sciences
Morbidity
Neonates
Newborn babies
Pediatric research
Pediatrics
People and Places
Physical Sciences
Pregnant women
Premature babies
Premature birth
Prenatal influences
Regression analysis
Respiratory distress syndrome
Retina
Retinopathy
Retinopathy of prematurity
Risk analysis
Risk factors
Sepsis
Statistical tests
Steroids
Studies
Vascular diseases
Vascularization
Weighing
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Summary:Retinopathy of prematurity (ROP) is a significant morbidity in preterm babies. Multiple risk factors for severe ROP have been extensively studied, however, only a few studies have included maternal diabetes mellitus (MDM) in their assessment. ROP and diabetic retinopathy are both retinal vascular diseases in which there is leakage and/or neovascularization from damaged retinal vessels. Diabetes may affect ROP development; however, there are conflicting results on the association between MDM and ROP. To determine if MDM is an independent risk factor for clinically significant ROP (ROP > Stage II) in neonates weighing less than 1500g. We conducted a retrospective cohort study of neonates weighing
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0236639