Biventricular myocardial adaptation in patients with repaired tetralogy of Fallot: Mechanistic insights from magnetic resonance imaging tissue phase mapping

• Published in: PloS one 2020-08, Vol.15 (8), p.e0237193-e0237193
• Main Authors: Chang, Meng-Chu, Wu, Ming-Ting, Weng, Ken-Pen, Chien, Kuang-Jen, Lin, Chu-Chuan, Su, Mao-Yuan, Lin, Ko-Long, Chang, Ming-Hua, Peng, Hsu-Hsia
• Format: Article
• Language: English
• Subjects: Biology and Life Sciences; Biomedical engineering; Cardiac stress tests; Cardiovascular disease; Catheters; Congenital diseases; Correlation; Development and progression; Diagnosis; Electrocardiography; Environmental science; Fitness equipment; Funding; Heart; Hospitals; Intubation; Laboratories; Magnetic resonance; Magnetic resonance imaging; Mapping; Medicine; Medicine and Health Sciences; Methods; Pediatrics; Physical Sciences; Pulmonary arteries; Pulmonary artery; Regurgitation; Research and Analysis Methods; Resonance; Software; Stenosis; Subgroups; Tetralogy of Fallot; Ventricle; Wu, Ting
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0237193

The myocardial adaptive mechanism in patients with repaired tetralogy of Fallot (rTOF) is less understood. We aimed to investigate biventricular myocardial adaptive remodeling in rTOF patients. We recruited 32 rTOF patients and 38 age- and sex-matched normal controls. The pulmonary stenosis of rTOF patients was measured using catheterized pressure gradient between right ventricle (RV) and pulmonary artery (PG.sub.RVPA). rTOF patients with PG.sub.RVPA < 15 mmHg and [greater than or equal to]15 mmHg were classified as low pulmonary stenosis (rTOF.sub.low, n = 19) and high pulmonary stenosis (rTOF.sub.high, n = 13) subgroups, respectively. Magnetic resonance imaging tissue phase mapping was employed to evaluate the voxelwise biventricular myocardial motion in longitudinal (Vz), radial (Vr), and circumferential (V[phi]) directions. The rTOF.sub.low subgroup presented higher pulmonary regurgitation fraction than rTOF.sub.high subgroup (p < 0.001). Compared with the normal group, only rTOF.sub.low subgroup presented a decreased RV ejection fraction (RVEF) (p < 0.05). The rTOF.sub.low subgroup showed decreased systolic and diastolic Vz in RV and LV, whereas rTOF.sub.high subgroup showed such change only in RV. In rTOF.sub.low subgroup, RVEF significantly correlated with RV systolic Vr (r = 0.56, p < 0.05), whereas LVEF correlated with LV systolic Vz (r = 0.51, p = 0.02). Prolonged QRS correlated with RV systolic Vr (r = -0.58, p < 0.01) and LV diastolic Vr (r = 0.81, p < 0.001). No such correlations occurred in rTOF.sub.high subgroup. The avoidance of unfavorable functional interaction in RV and LV in rTOF.sub.high subgroup suggested that adequate pulmonary stenosis (PG.sub.RVPA [greater than or equal to] 15 mmHg in this sereis) has a protective effect against pulmonary regurgitation.