Effects of microsurface structure of bioactive nanoparticles on dentinal tubules as a dentin desensitizer

In this in vitro study, spherical mesoporous bioactive glass nanoparticle (MBGN) and non-porous bioactive glass nanoparticle (BGN) were fabricated. The impact of mesopores on dentinal tubule occlusion and bioactivity was compared to examine the potential of these materials in alleviating dentine hyp...

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Bibliographic Details
Published in:PloS one 2020-08, Vol.15 (8), p.e0237726-e0237726
Main Authors: Choi, Yang-Jung, Bae, Moon-Kyoung, Kim, Yong-Il, Park, Jeong-Kil, Son, Sung-Ae, Bakhsheshi-Rad, Hamid Reza
Format: Article
Language:English
Subjects:
Acids
Biocompatibility
Bioglass
Biological activity
Biology and Life Sciences
Biomaterials
Bonding strength
Care and treatment
Cell viability
Citric acid
Composite materials
Cytotoxicity
Dental research
Dentin
Dentistry
Earth Sciences
Engineering and Technology
Ethanol
Fourier transforms
Hydroxyapatite
Hypersensitivity
Medicine and Health Sciences
Methods
Nanoparticles
Occlusion
Physical Sciences
Physiological aspects
Remineralization
Sol-gel processes
Structure
Tooth diseases
Toxicity
Tubules
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Summary:In this in vitro study, spherical mesoporous bioactive glass nanoparticle (MBGN) and non-porous bioactive glass nanoparticle (BGN) were fabricated. The impact of mesopores on dentinal tubule occlusion and bioactivity was compared to examine the potential of these materials in alleviating dentine hypersensitivity (DH). MBGN, dense BGN were synthesized by sol-gel methods and characterized. Bioactivity and ion dissolution ability were analyzed. Twenty-four simulated sensitive dentin discs were prepared and randomly divided into three groups (n = 8 each); Group 1, no treatment; Group 2, Dense BGN; Group 3, MBGN. Then, four discs per group were treated with 6wt.% citric acid challenge to determine the acidic resistance. The effects on dentinal tubule occlusion were observed by FESEM. The microtensile bond strength (MTBS) was also measured. Cytotoxicity was examined using the MTT assay. According to the results, dense BGN without mesopore and MBGN with mesopore were successfully fabricated. Dense BGN and MBGN occluded the dentinal tubule before and after acid challenge. However, only MBGN formed a membrane-like layer and showed hydroxyapatite formation after soaking SBF solution. There were no significant differences in MTBS among dense BGN, MBGN (P>0.05). The cell viability was above 72% of both materials. The higher bioactivity of MBGN compared with that of dense BGN arises from the structural difference and it is anticipated to facilitate dentin remineralization by inducing hydroxyapatite deposition within the dentinal tubule.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0237726