Lipids, biomarkers, and subclinical atherosclerosis in treatment-naive HIV patients starting or not starting antiretroviral therapy: Comparison with a healthy control group in a 2-year prospective study

To assess the effect of HIV infection and combined antiretroviral therapy (c-ART) on various proatherogenic biomarkers and lipids and to investigate their relationship with subclinical atherosclerosis in a cohort of treatment-naive HIV-infected patients. We performed a prospective, comparative, mult...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2020-08, Vol.15 (8), p.e0237739-e0237739
Main Authors: Di Yacovo, Silvana, Saumoy, Maria, Sanchez-Quesada, Jose Luis, Navarro, Antonio, Sviridov, Dmitri, Javaloyas, Manuel, Vila, Ramon, Vernet, Anton, Low, Hann, Penafiel, Judith, Garcia, Benito, Ordonez-Llanos, Jordi, Podzamczer, Daniel
Format: Article
Language:English
Subjects:
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Apolipoproteins
Arteriosclerosis
Atherosclerosis
Biochemistry
Biological markers
Biology and Life Sciences
Biomarkers
Biomedical research
Blood lipids
C-reactive protein
Cardiovascular disease
Care and treatment
CD4 antigen
Cholesterol
Coronary vessels
Development and progression
Diabetes
Diagnosis
Drug therapy
Evaluation
Genotype & phenotype
Health aspects
High density lipoprotein
Highly active antiretroviral therapy
HIV
HIV patients
Human immunodeficiency virus
Infections
Infectious diseases
Inflammation
Interleukin
Interleukin 6
Laboratories
Lipids
Lipoproteins
Low density lipoprotein
Medicine and Health Sciences
Metabolism
Methods
Molecular biology
Monocyte chemoattractant protein
Monocyte chemoattractant protein 1
Monocytes
Patient outcomes
Phenotypes
Phospholipase
Phospholipase A2
Plasma levels
Population studies
Proteins
Studies
Thickness
Ultrasonic imaging
Ultrasound
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To assess the effect of HIV infection and combined antiretroviral therapy (c-ART) on various proatherogenic biomarkers and lipids and to investigate their relationship with subclinical atherosclerosis in a cohort of treatment-naive HIV-infected patients. We performed a prospective, comparative, multicenter study of 2 groups of treatment-naive HIV-infected patients (group A, CD4>500 cells/[mu]L, not starting c-ART; and group B, CD4
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0237739