Effect of ventilation rate on recovery after cardiac arrest in a pediatric animal model

To assess the impact of two different respiratory rates in hemodynamic, perfusion and ventilation parameters in a pediatric animal model of cardiac arrest (CA). An experimental randomized controlled trial was carried out in 50 piglets under asphyxial CA. After ROSC, they were randomized into two gro...

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Bibliographic Details
Published in:PloS one 2020-08, Vol.15 (8), p.e0237736-e0237736
Main Authors: López, Jorge, Arias, Patricia, Domenech, Beatriz, Horcajo, Daniel, Nocete, Juan Pablo, Zamora, Laura, Fernández, Sarah Nicole, López-Herce, Jesús
Format: Article
Language:English
Subjects:
Animal models
Animals
Arterial Pressure - physiology
Asphyxia
Asphyxia - physiopathology
Asphyxia - therapy
Biology and Life Sciences
Blood pressure
Carbon dioxide
Carbon Dioxide - metabolism
Cardiac arrest
Cardiopulmonary resuscitation
Chi-square test
Children & youth
Childrens health
Continuity (mathematics)
Control methods
CPR
Development and progression
Disease Models, Animal
Fentanyl
Health aspects
Heart Arrest - physiopathology
Heart Arrest - therapy
Heart rate
Hemodynamics
Hospitals
Hyperventilation
Intensive care
Lactic acid
Lactic Acid - metabolism
Mathematical models
Mechanical ventilation
Medical research
Medicine
Medicine and Health Sciences
Oxygen saturation
Parameters
Partial pressure
Pediatric research
Pediatrics
Perfusion
Pulmonary ventilation
Randomization
Recovery (Medical)
Research and Analysis Methods
Respiration
Respiratory rate
Respiratory Rate - physiology
Statistical tests
Statistics, Nonparametric
Studies
Supervision
Swine - physiology
Ventilation
Ventilation - standards
Ventilators
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Description
Summary:To assess the impact of two different respiratory rates in hemodynamic, perfusion and ventilation parameters in a pediatric animal model of cardiac arrest (CA). An experimental randomized controlled trial was carried out in 50 piglets under asphyxial CA. After ROSC, they were randomized into two groups: 20 and 30 respirations per minute (rpm). Hemodynamic, perfusion and ventilation parameters were measured 10 minutes after asphyxia, just before ROSC and at 5, 15, 30 and 60 minutes after ROSC. Independent medians test, Kruskal-Wallis test and χ2 test, were used to compare continuous and categorical variables, respectively. Spearman's Rho was used to assess correlation between continuous variables. A p-value
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0237736