Incidence of intussusception before and after the introduction of rotavirus vaccine in Korea

Recent studies have reported that after the introduction of rotavirus vaccine the incidence of intussusception did not change among infants, or slightly increased at the age immediately after the first dose. The rotavirus vaccines were introduced in Korea for private market use in 2007-2008. We inve...

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Published in:PloS one 2020-08, Vol.15 (8), p.e0238185-e0238185
Main Authors: Cho, Hye-Kyung, Hwang, Se Hwan, Nam, Hye Na, Han, Kyungdo, Kim, Bongsung, Kong, Insik, Park, Kwangsuk, Lee, Jaeyoung
Format: Article
Language:English
Subjects:
Age
Age groups
Babies
Biology and Life Sciences
Demographic aspects
Disease control
Disease prevention
Health aspects
Health insurance
Hernias
Immunization
Infants
Insurance coverage
Intestinal obstruction
Intussusception
Licenses
Licensing, certification and accreditation
Medical schools
Medicine
Medicine and Health Sciences
Pediatric research
Pediatrics
People and Places
Population
Prevention
Risk factors
Rotavirus
Rotavirus infections
Statistics
Trends
Vaccines
Viral vaccines
Viruses
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description Recent studies have reported that after the introduction of rotavirus vaccine the incidence of intussusception did not change among infants, or slightly increased at the age immediately after the first dose. The rotavirus vaccines were introduced in Korea for private market use in 2007-2008. We investigated the incidence of intussusception before (2002-2006) and after (2009-2015) the vaccine introduction in Korea. We conducted an interrupted time series study that used data from the Korean National Health Insurance database to identify infants (
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The rotavirus vaccines were introduced in Korea for private market use in 2007-2008. We investigated the incidence of intussusception before (2002-2006) and after (2009-2015) the vaccine introduction in Korea. We conducted an interrupted time series study that used data from the Korean National Health Insurance database to identify infants (&lt;12 months of age) who were diagnosed with intussusception and underwent non-invasive or invasive reduction from 2002 to 2015. According to the recommended ages for immunization, the annual intussusception incidence and the incidence rate ratios were calculated among three age groups, 6-14, 15-24, and 25-34 weeks. The annual incidences in infants have decreased over time from 241.7 per 100,000 infants (pre-vaccine period) to 160.1-205.2 per 100,000 infants (post-vaccine period). The incidence rate ratio during the post-vaccine period ranged from 0.66 to 0.85. The incidences of intussusception in all three infant age groups have decreased in post-vaccine period compared to pre-vaccine period (incidence rate ratio range: 0.31-0.65, 0.47-0.75, and 0.68-0.94 in 6-14, 15-24, and 25-34 weeks, respectively). The incidence of intussusception in infants did not increase after the rotavirus vaccine introduction in Korea, but rather decreased over the past decades. 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The rotavirus vaccines were introduced in Korea for private market use in 2007-2008. We investigated the incidence of intussusception before (2002-2006) and after (2009-2015) the vaccine introduction in Korea. We conducted an interrupted time series study that used data from the Korean National Health Insurance database to identify infants (&lt;12 months of age) who were diagnosed with intussusception and underwent non-invasive or invasive reduction from 2002 to 2015. According to the recommended ages for immunization, the annual intussusception incidence and the incidence rate ratios were calculated among three age groups, 6-14, 15-24, and 25-34 weeks. The annual incidences in infants have decreased over time from 241.7 per 100,000 infants (pre-vaccine period) to 160.1-205.2 per 100,000 infants (post-vaccine period). The incidence rate ratio during the post-vaccine period ranged from 0.66 to 0.85. The incidences of intussusception in all three infant age groups have decreased in post-vaccine period compared to pre-vaccine period (incidence rate ratio range: 0.31-0.65, 0.47-0.75, and 0.68-0.94 in 6-14, 15-24, and 25-34 weeks, respectively). The incidence of intussusception in infants did not increase after the rotavirus vaccine introduction in Korea, but rather decreased over the past decades. 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The rotavirus vaccines were introduced in Korea for private market use in 2007-2008. We investigated the incidence of intussusception before (2002-2006) and after (2009-2015) the vaccine introduction in Korea. We conducted an interrupted time series study that used data from the Korean National Health Insurance database to identify infants (&lt;12 months of age) who were diagnosed with intussusception and underwent non-invasive or invasive reduction from 2002 to 2015. According to the recommended ages for immunization, the annual intussusception incidence and the incidence rate ratios were calculated among three age groups, 6-14, 15-24, and 25-34 weeks. The annual incidences in infants have decreased over time from 241.7 per 100,000 infants (pre-vaccine period) to 160.1-205.2 per 100,000 infants (post-vaccine period). The incidence rate ratio during the post-vaccine period ranged from 0.66 to 0.85. The incidences of intussusception in all three infant age groups have decreased in post-vaccine period compared to pre-vaccine period (incidence rate ratio range: 0.31-0.65, 0.47-0.75, and 0.68-0.94 in 6-14, 15-24, and 25-34 weeks, respectively). The incidence of intussusception in infants did not increase after the rotavirus vaccine introduction in Korea, but rather decreased over the past decades. Since the incidence of intussusception varies according to country or region, continuous monitoring the incidence of intussusception in infants is necessary in each county or region.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32857776</pmid><doi>10.1371/journal.pone.0238185</doi><tpages>e0238185</tpages><orcidid>https://orcid.org/0000-0003-0990-1350</orcidid><oa>free_for_read</oa></addata></record>
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subjects Age
Age groups
Babies
Biology and Life Sciences
Demographic aspects
Disease control
Disease prevention
Health aspects
Health insurance
Hernias
Immunization
Infants
Insurance coverage
Intestinal obstruction
Intussusception
Licenses
Licensing, certification and accreditation
Medical schools
Medicine
Medicine and Health Sciences
Pediatric research
Pediatrics
People and Places
Population
Prevention
Risk factors
Rotavirus
Rotavirus infections
Statistics
Trends
Vaccines
Viral vaccines
Viruses
title Incidence of intussusception before and after the introduction of rotavirus vaccine in Korea
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