Plasma volume, cell volume, total blood volume and F factor in the tree shrew

In this study, the physiological values of volumes of plasma, cells, total blood and the F blood factors were identified in 24 adult tree shrews (Tupaia belangeri; 12 male and 12 female; average BW of 123.9±19.19 g). The two-compartment model method of Evans Blue dye was used to obtain the plasma vo...

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Bibliographic Details
Published in:PloS one 2020-09, Vol.15 (9), p.e0234835-e0234835
Main Authors: Xia, Wei, Huang, Zong-jian, Guo, Zhao-liang, Feng, Yi-wei, Zhang, Chao-yin, He, Guang-yao, Tang, An-zhou
Format: Article
Language:English
Subjects:
Animals
Biology and Life Sciences
Blood
Blood volume
Body weight
Cell size
Education
Erythrocytes
Femur
Gender
Heart
Hematocrit
Hemodynamics
Jugular vein
Labeling
Laboratories
Medicine and Health Sciences
Otolaryngology
Physiological effects
Plasma
Prevention
Red blood cells
Soricidae
Surgery
Variance analysis
Veins
Veins & arteries
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Summary:In this study, the physiological values of volumes of plasma, cells, total blood and the F blood factors were identified in 24 adult tree shrews (Tupaia belangeri; 12 male and 12 female; average BW of 123.9±19.19 g). The two-compartment model method of Evans Blue dye was used to obtain the plasma volume and the venous hematocrit was measured by microhematocrit method. To establish the relationship between body weight (BW) and blood volume of tree shrews, We performed linear fitting for these two datasets. Results were analyzed according to gender and weight (120g). Statistical significance was assessed using the unpaired student t test and one-way ANOVA. The average volumes per 100g body weight of plasma, red blood cell (RBC) and total blood were 5.42±0.543, 3.24±0.445, and 8.66±0.680ml respectively. The mean body hematocrit, cardiac hematocrit, jugular vein hematocrit, femoral vein hematocrit, and tail vein hematocrit was 37.43±4.096, 39.72±3.219, 43.04±4.717, 40.84±3.041, and 38.71±3.442% respectively. The F cardiac was 0.94±0.072, F jugular vein 0.88±0.118, F femoral vein 0.92±0.111, and the F tail vein 0.97±0.117. Blood volume (ml) was 85.89103×BW (kg). This is the first study to provide the parameters of plasma volume, cell volume, total blood volume and F factor and a baseline for future research on blood physiology of tree shrews.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0234835